{"id":7663,"date":"2016-07-25T21:50:20","date_gmt":"2016-07-25T19:50:20","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/en\/forschung\/"},"modified":"2025-04-23T08:29:55","modified_gmt":"2025-04-23T06:29:55","slug":"research","status":"publish","type":"page","link":"https:\/\/www.humangenetik-umg.de\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"
[mk_page_section bg_image=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/LHA0034-forschung-1900.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” min_height=”600″ full_width=”true” el_class=”header-bild” sidebar=”sidebar-1″][vc_column][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_empty_space height=”50px”][vc_column_text align=”center” el_class=”forschung”]\n

Research<\/span><\/h1>\n[\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner css=”.vc_custom_1469628780691{padding-right: 20px !important;}”][vc_column_text css=”.vc_custom_1678277818821{margin-bottom: 0px !important;}”]Rapid technological advances have opened new horizons for human genetics research: Genome sequencing can detect nearly all changes in our DNA. With CRISPR\/Cas9, one of the most powerful new genomic editing tools of the past decades, it is now possible to edit DNA in a targeted manner, to efficiently switch genes on or off, or to correct specific disease-causing mutations. OMICs technologies provide a range of tools to monitor DNA, RNA, proteins, metabolites and other molecules within the cell.<\/p>\n

Our Institute is strongly committed and well equipped to seize the immense potential of these new technologies. Our researchers are creative and passionate in continuously devising innovative strategies to identify genetic changes and to analyze their consequences. They uncover disease-associated gene variants, characterize their functional impact, shed new light on fundamental biological processes, explore cellular and molecular processes in aging and aging-related diseases and provide deeper insights into the development and therapy of cancer.<\/p>\n

The MutationMining Team (MM Team) is a unique feature of our Institute. Brought together in this multidisciplinary team, clinicians and scientists coming from various backgrounds interpret sequencing data from a clinical genetics perspective to identify novel disease-associated genes and variants in research projects either within the Institute or in collaborations with other research teams.<\/p>\n

In all our research we work toward the goal of bridging the gap between science and clinical practice. Our motivation is to improve diagnostics of genetic disorders and to inform development of new therapeutic options.<\/p>\n

The projects of our research groups are funded by Deutsche Forschungsgemeinschaft (DFG), German Center for Heart and Cardiovascular Research (DZHK), German Federal Ministry of Education and Research (BMBF) and other funding organizations.
\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”80px”][\/vc_column][\/mk_page_section][vc_row fullwidth=”true” fullwidth_content=”false” css=”.vc_custom_1470053634623{background-color: #ffcc33 !important;}” el_class=”ankernavigation-dark”][vc_column width=”1\/3″ el_class=”anker-first”][mk_fancy_title color=”#ffffff” size=”30″ margin_bottom=”0″ font_family=”none” align=”center” animation=”scale-up”]Main Research Areas<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=”1\/3″ el_class=”anker-middle” css=”.vc_custom_1476101240269{border-right-width: 2px !important;border-left-width: 2px !important;}”][mk_fancy_title color=”#ffffff” size=”30″ margin_bottom=”0″ font_family=”none” align=”center” animation=”scale-up”]MM Team
\n<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=”1\/3″ el_class=”anker-middle”][mk_fancy_title color=”#ffffff” size=”30″ margin_bottom=”0″ font_family=”none” align=”center” animation=”scale-up”]Section of<\/span>
\nMolecular Developmental
\nGenetics<\/a>[\/mk_fancy_title][\/vc_column][\/vc_row][mk_page_section min_height=”0″ padding_top=”0″ padding_bottom=”0″ sidebar=”sidebar-1″][vc_column][mk_padding_divider visibility=”hidden-sm”][\/vc_column][\/mk_page_section][vc_row fullwidth=”true” fullwidth_content=”false” css=”.vc_custom_1470053634623{background-color: #ffcc33 !important;}” el_class=”ankernavigation-dark”][vc_column width=”1\/2″ el_class=”anker-first”][mk_fancy_title color=”#ffffff” size=”30″ margin_bottom=”0″ font_family=”none” align=”center” animation=”scale-up”]Research Groups<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=”1\/2″ el_class=”anker-middle”][mk_fancy_title color=”#ffffff” size=”30″ margin_bottom=”0″ font_family=”none” align=”center” animation=”scale-up”]Publications<\/a>[\/mk_fancy_title][\/vc_column][\/vc_row][mk_page_section min_height=”0″ padding_top=”0″ padding_bottom=”0″ section_id=”anker-1″ sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”120″ visibility=”hidden-sm”][mk_padding_divider size=”100″][\/vc_column][\/mk_page_section][mk_page_section section_id=”main-research-areas” sidebar=”sidebar-1″][vc_column width=”1\/3″][vc_row_inner][vc_column_inner][vc_empty_space][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/spektrum-content_490x846.jpg” image_size=”full”][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/forschung_180x180.jpg” image_size=”full” align=”right” visibility=”hidden-sm” el_class=”padding30t”][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”2\/3″][vc_row_inner][vc_column_inner][vc_column_text el_class=”titlebox forschung-01″ css=”.vc_custom_1591356980939{margin-bottom: 0px !important;}”]\n

Main Research Areas<\/h2>\n

<\/h3>\n[\/vc_column_text][mk_padding_divider size=”25″ visibility=”visible-sm”][mk_padding_divider visibility=”hidden-sm”][vc_column_text el_class=”padding25lr” css=”.vc_custom_1678355689679{margin-bottom: 0px !important;}”]The range of our research activities is wide and covers fundamental biological processes like aging, pathogenesis of rare diseases and cancers as well as the development of novel therapeutic options based on genome editing…[\/vc_column_text][vc_empty_space][mk_button dimension=”flat” size=”medium” icon=”mk-icon-long-arrow-right” icon_anim=”side” url=”\/en\/research\/main-research-areas” id=”button-forschung” el_class=”button-forschung-01″ bg_color=”#ffcc33″ btn_hover_bg=”#000000″ text_color=”dark” btn_hover_txt_color=”#ffffff”]learn more[\/mk_button][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section section_id=”M-Team” sidebar=”sidebar-1″][vc_column][mk_padding_divider visibility=”visible-sm”][mk_padding_divider size=”200″ visibility=”hidden-sm”][\/vc_column][\/mk_page_section][mk_page_section section_id=”MM-Team” sidebar=”sidebar-1″][vc_column width=”2\/3″][vc_row_inner][vc_column_inner][vc_column_text el_class=”titlebox forschung-02″ css=”.vc_custom_1591357015066{margin-bottom: 0px !important;}”]\n

Mutation\u00adMining Team<\/h2>\n[\/vc_column_text][mk_padding_divider visibility=”hidden-sm”][mk_padding_divider size=”25″ visibility=”visible-sm”][vc_column_text el_class=”padding25lr” css=”.vc_custom_1678355627648{margin-bottom: 0px !important;}”]New high-throughput technologies and, above all, next generation sequencing (NGS) technologies as whole-genome or whole-exome sequencing have made it easier to discover disease-associated genes and disease-causing mutations. Our MutationMining (MM) Team searches the data generated by NGS-based analyses to detect novel causative genes and mutations in patients with various rare genetic diseases and undiagnosed congenital syndromes…[\/vc_column_text][vc_empty_space][mk_button dimension=”flat” size=”medium” icon=”mk-icon-long-arrow-right” icon_anim=”side” url=”\/en\/research\/mm-team” id=”button-forschung” bg_color=”#ff9900″ btn_hover_bg=”#000000″ text_color=”dark” btn_hover_txt_color=”#ffffff”]learn more[\/mk_button][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/3″][vc_row_inner][vc_column_inner][vc_empty_space][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/mm-team-content_490x846-1.jpg” image_size=”full” margin_bottom=”0″][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/contentbilder-180x287_m-team.jpg” image_size=”full” visibility=”hidden-sm” el_class=”padding30t”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section section_id=”molekulare-entwicklungsgenetik” sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”200″ visibility=”hidden-sm”][mk_padding_divider visibility=”visible-sm”][\/vc_column][\/mk_page_section][mk_page_section section_id=”molecular-developmental-genetics” sidebar=”sidebar-1″][vc_column width=”1\/3″][vc_row_inner][vc_column_inner][vc_empty_space][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/molekulare-entwicklungsgenetik-490×846.jpg” image_size=”full”][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/forschung_180x180.jpg” image_size=”full” align=”right” visibility=”hidden-sm” el_class=”padding30t”][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”2\/3″][vc_row_inner][vc_column_inner][vc_column_text el_class=”titlebox forschung-01″ css=”.vc_custom_1591357055047{margin-bottom: 0px !important;}”]Section of<\/span><\/p>\n

Molecular
\nDevelopmental Genetics<\/h2>\n[\/vc_column_text][mk_padding_divider size=”25″ visibility=”visible-sm”][mk_padding_divider visibility=”hidden-sm”][vc_column_text el_class=”padding25lr” css=”.vc_custom_1591357065054{margin-bottom: 0px !important;}”]Cancer can be linked to signaling pathways that play an important role during embryonal development. Our goal is to understand the role of the \u201eHedgehog\u201c and \u201eWnt\u201c signaling cascades in the formation and progression of tumors of the skeletal muscle, the skin and of the brain. In addition, we are analyzing the impact of specific stem cells in tumor development. Our projects are supported by the German Research Foundation, the Wilhelm-Sander-Stiftung und the German Cancer Aid….[\/vc_column_text][vc_empty_space][mk_button dimension=”flat” size=”medium” icon=”mk-icon-long-arrow-right” icon_anim=”side” url=”\/en\/research\/molecular-developmental-genetics” id=”button-forschung” el_class=”button-forschung-01″ bg_color=”#ffcc33″ btn_hover_bg=”#000000″ text_color=”dark” btn_hover_txt_color=”#ffffff”]learn more[\/mk_button][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section section_id=”arbeitsgruppen” sidebar=”sidebar-1″][vc_column][mk_padding_divider visibility=”visible-sm”][mk_padding_divider size=”200″ visibility=”hidden-sm”][\/vc_column][\/mk_page_section][mk_page_section section_id=”research-groups” sidebar=”sidebar-1″][vc_column width=”1\/3″ offset=”vc_hidden-xs”][vc_row_inner][vc_column_inner][vc_empty_space][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/arbeitsgruppen-490×846.jpg” image_size=”full”][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/forschung_180x180.jpg” image_size=”full” align=”right” visibility=”hidden-sm” el_class=”padding30t”][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”2\/3″][vc_row_inner][vc_column_inner][vc_column_text el_class=”titlebox forschung-03″ css=”.vc_custom_1591357096674{margin-bottom: 0px !important;}”]\n

Research Groups<\/h2>\n[\/vc_column_text][mk_padding_divider visibility=”hidden-sm”][mk_padding_divider size=”25″ visibility=”visible-sm”][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/2″][mk_button dimension=”flat” size=”large” align=”center” fullwidth=”true” margin_right=”0″ bg_color=”#ffcc33″ btn_hover_bg=”#ffcc33″ text_color=”dark” btn_hover_txt_color=”#000000″]Kaulfu\u00df Group[\/mk_button][\/vc_column_inner][vc_column_inner width=”1\/2″][mk_button dimension=”flat” size=”large” icon=”mk-icon-long-arrow-right” icon_anim=”side” url=”\/kornak-research-group\/” align=”center” fullwidth=”true” margin_right=”0″ bg_color=”#ffcc33″ btn_hover_bg=”#000000″ text_color=”dark” btn_hover_txt_color=”#ffffff”]Kornak Group[\/mk_button][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/2″][mk_button dimension=”flat” size=”large” icon=”mk-icon-long-arrow-right” icon_anim=”side” url=”\/en\/research\/pauli-research-group” align=”center” fullwidth=”true” margin_right=”0″ bg_color=”#ffcc33″ btn_hover_bg=”#000000″ text_color=”dark” btn_hover_txt_color=”#ffffff”]Pauli Group[\/mk_button][\/vc_column_inner][vc_column_inner width=”1\/2″][mk_button dimension=”flat” size=”large” icon=”mk-icon-long-arrow-right” icon_anim=”side” url=”\/molecular-developmental-genetics\/” align=”center” fullwidth=”true” margin_right=”0″ bg_color=”#ffcc33″ btn_hover_bg=”#000000″ text_color=”dark” btn_hover_txt_color=”#ffffff”]Uhmann\/Hahn Group[\/mk_button][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/2″][mk_button dimension=”flat” size=”large” icon=”mk-icon-long-arrow-right” icon_anim=”side” url=”\/en\/research\/wollnik-research-group” align=”center” fullwidth=”true” margin_right=”0″ bg_color=”#ffcc33″ btn_hover_bg=”#000000″ text_color=”dark” btn_hover_txt_color=”#ffffff”]Wollnik Group[\/mk_button][\/vc_column_inner][vc_column_inner width=”1\/2″][mk_button dimension=”flat” size=”large” align=”center” fullwidth=”true” margin_right=”0″ bg_color=”#ffcc33″ btn_hover_bg=”#ffcc33″ text_color=”dark” btn_hover_txt_color=”#000000″]Zibat Group[\/mk_button][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section min_height=”30″ sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”80″ visibility=”visible-sm”][mk_padding_divider size=”200″ visibility=”hidden-sm”][\/vc_column][\/mk_page_section][mk_page_section section_id=”publications” sidebar=”sidebar-1″][vc_column width=”2\/3″][vc_row_inner][vc_column_inner][vc_column_text el_class=”titlebox forschung-02″ css=”.vc_custom_1591357141493{margin-bottom: 0px !important;}”]\n

Publications<\/h2>\n[\/vc_column_text][mk_padding_divider visibility=”hidden-sm”][mk_padding_divider size=”25″ visibility=”visible-sm”][vc_empty_space][mk_button dimension=”flat” size=”medium” icon=”mk-icon-long-arrow-right” icon_anim=”side” url=”\/en\/research\/publications” align=”right” id=”button-forschung” bg_color=”#ff9900″ btn_hover_bg=”#000000″ text_color=”dark” btn_hover_txt_color=”#ffffff”]show all[\/mk_button][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/3″ offset=”vc_hidden-xs”][vc_empty_space][vc_empty_space][vc_empty_space][vc_empty_space][vc_row_inner][vc_column_inner][vc_icon icon_fontawesome=”fa fa-file-text-o” color=”custom” size=”xl” css_animation=”none” custom_color=”#ff9900″ el_class=”vc-icon-extra-large hidden-on-mobile”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section min_height=”0″ padding_top=”0″ padding_bottom=”0″ section_id=”molekulargenetische-diagnostik” sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”200″ visibility=”hidden-sm”][mk_padding_divider visibility=”visible-sm”][\/vc_column][\/mk_page_section]\n<\/div>","protected":false},"excerpt":{"rendered":"

[mk_page_section bg_image=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/LHA0034-forschung-1900.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” min_height=”600″ full_width=”true” el_class=”header-bild” sidebar=”sidebar-1″][vc_column][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_empty_space height=”50px”][vc_column_text align=”center” el_class=”forschung”] Research [\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner css=”.vc_custom_1469628780691{padding-right: 20px !important;}”][vc_column_text css=”.vc_custom_1678277818821{margin-bottom: 0px !important;}”]Rapid technological advances have opened new horizons for human genetics research: Genome sequencing can detect nearly all changes in our DNA. With CRISPR\/Cas9, one of the most powerful new genomic editing tools […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7663","page","type-page","status-publish","hentry"],"yoast_head":"\nResearch - Institute of Human Genetics<\/title>\n<meta name=\"description\" content=\"Our researchers make use of the immense potential of the new technologies of NGS, CRISPR\/Cas and Omics to identify genetic changes and to analyze their consequences.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - Institute of Human Genetics\" \/>\n<meta property=\"og:description\" content=\"Our researchers make use of the immense potential of the new technologies of NGS, CRISPR\/Cas and Omics to identify genetic changes and to analyze their consequences.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-23T06:29:55+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/research\/\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/research\/\",\"name\":\"Research - 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