{"id":7725,"date":"2016-03-24T10:17:37","date_gmt":"2016-03-24T09:17:37","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/en\/forschung\/spektrum\/"},"modified":"2025-12-15T15:21:45","modified_gmt":"2025-12-15T14:21:45","slug":"main-research-areas","status":"publish","type":"page","link":"https:\/\/www.humangenetik-umg.de\/en\/research\/main-research-areas\/","title":{"rendered":"Main Research Areas"},"content":{"rendered":"
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Main Research Areas<\/span><\/h1>\n[\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner css=”.vc_custom_1469979627686{padding-right: 20px !important;padding-left: 20px !important;}”][vc_column_text css=”.vc_custom_1678278872109{margin-bottom: 0px !important;}”]Our Institute provides a modern and dynamic infrastructure for our researchers to produce findings that expand our understanding of fundamental biological processes, improve diagnostics of genetic disorders and inform development of future therapeutic options for the benefit of patients.<\/p>\n

The range of our research activities is wide. This is a selection of key issues and disorders that our research groups focus on: [\/vc_column_text][mk_padding_divider][vc_column_text css=”.vc_custom_1678357940007{margin-bottom: 0px !important;}”]Molecular & cellular mechanisms of aging<\/strong><\/p>\n

What genes, signalling pathways and mechanisms are involved in the physiological process of aging, in rare congenital disorders with premature aging and in the pathogenesis of aging-related diseases?
\n\u21d2 Research groups Kornak<\/a>, Wollnik<\/a>[\/vc_column_text][mk_padding_divider][vc_column_text css=”.vc_custom_1678357733646{margin-bottom: 0px !important;}”]Novel therapeutic options by genome editing<\/strong><\/p>\n

How can we use CRISPR\/Cas technology to develop specific molecular therapies for congenital disorders as for example heart diseases or bone disorders?
\n\u21d2 Research groups Kornak<\/a>, Wollnik<\/a>[\/vc_column_text][mk_padding_divider][vc_column_text css=”.vc_custom_1678357952377{margin-bottom: 0px !important;}”]Identifying genes & unravelling molecular mechanisms<\/strong><\/p>\n

We identify novel genes and variants related to rare diseases and explore gene functions and variant effects on molecular mechanisms.
\n\u21d2 Research groups Kornak<\/a>, Pauli<\/a>, Wollnik<\/a>[\/vc_column_text][mk_padding_divider][vc_column_text css=”.vc_custom_1765808547143{margin-bottom: 0px !important;}”]Hereditary hearing loss<\/strong><\/p>\n

We aim to find new genes or gene variants that are associated with syndromic or non-syndromic forms of hereditary hearing loss.
\n\u21d2 Research group Wollnik<\/a>[\/vc_column_text][mk_padding_divider][vc_column_text css=”.vc_custom_1678357757693{margin-bottom: 0px !important;}”]Pathogenesis of cancer<\/strong><\/p>\n

What signalling pathways interact in the pathogenesis of rhabdomyosarcoma and pituitary adenoma?
\n\u21d2 Section of Molecular Developmental Genetics<\/a>
\nWhat genes and gene variants are involved in familial cancers?
\n\u21d2 Research groups Kaulfu\u00df, Wollnik<\/a>[\/vc_column_text][mk_padding_divider][vc_column_text css=”.vc_custom_1678357764598{margin-bottom: 0px !important;}”]Bioinformatic analysis of genome dynamics<\/strong><\/p>\n

Our NGS-based analyses generate enormous amounts of complex data. We develop and establish in-house bioinformatic pipelines that allow us to apply mathematical and statistical tools for processing, analyzing and interpreting data in a manner that provides new insights into various aspects of genome dynamics.
\n\u21d2 Research group Zibat[\/vc_column_text][mk_padding_divider][\/vc_column_inner][\/vc_row_inner][vc_row_inner is_fullwidth_content=”false”][vc_column_inner css=”.vc_custom_1469979627686{padding-right: 20px !important;padding-left: 20px !important;}”][vc_column_text css=”.vc_custom_1678280548939{margin-bottom: 0px !important;}”]We investigate molecular processes in single cells, in various tissues, at different times in the course of development, in healthy organisms and in disease. For this, we use state-of-the-art next-generation sequencing technology including genome sequencing, transcriptome analysis, single-cell sequencing and other methods. Experiments in cell systems as, e.g., iPS cells, organoids, bone-on-a-chip or in model organisms (mouse, zebrafish) improve our understanding of how mutations impact on protein function and how proteins interact in molecular mechanisms and signalling cascades. [\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][vc_row][vc_column][vc_empty_space height=”100px”][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"

[mk_page_section bg_image=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/03\/LHA9947-spektrum-1900.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” min_height=”600″ full_width=”true” section_id=”header-bild” sidebar=”sidebar-1″][vc_column][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_empty_space height=”50px”][vc_column_text] Main Research Areas [\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner css=”.vc_custom_1469979627686{padding-right: 20px !important;padding-left: 20px !important;}”][vc_column_text css=”.vc_custom_1678278872109{margin-bottom: 0px !important;}”]Our Institute provides a modern and dynamic infrastructure for our researchers to produce findings that expand our understanding of fundamental biological processes, improve diagnostics of genetic disorders and inform development […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7663,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7725","page","type-page","status-publish","hentry"],"yoast_head":"\nMain Research Areas - 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