{"id":7912,"date":"2016-03-24T10:14:06","date_gmt":"2016-03-24T09:14:06","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/en\/genetic-testing\/zytogenetische-diagnostik\/"},"modified":"2024-10-10T14:25:09","modified_gmt":"2024-10-10T12:25:09","slug":"cytogenetics","status":"publish","type":"page","link":"https:\/\/www.humangenetik-umg.de\/en\/genetic-testing\/cytogenetics\/","title":{"rendered":"Cytogenetics"},"content":{"rendered":"
[mk_page_section bg_image=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/03\/LHA98622-Beratung-1900.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” min_height=”500″ full_width=”true” section_id=”header-bild” sidebar=”sidebar-1″][vc_column][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_empty_space height=”50px”][vc_column_text align=”center”]\n

Cytogenetics<\/span><\/h1>\n[\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner][vc_column_text css=”.vc_custom_1535095981922{margin-bottom: 0px !important;}”]In classical cytogenetic diagnostics, we investigate chromosomes under the light microscope to detect anomalies affecting their number (aneuploidies) or their structure (e.g. inversions, translocations, duplications or deletions). This conventional method of chromosome analysis continues to be an important diagnostic procedure for example in patients with a history of multiple miscarriages, infertility, psychomotoric developmental delay and others and is applied for prenatal or postnatal testing.<\/p>\n

We also offer additional molecular cytogenetic analysis (FISH) for example in patients with suspected mosaicism (also using buccal swabs) and in patients with suspected DiGeorge syndrome or Williams-Beuren syndrome. If you are interested in these additional diagnostic tests, please contact us at +49-551-39-67596<\/a>.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][vc_row fullwidth=”true” fullwidth_content=”false” css=”.vc_custom_1476443647979{border-top-width: 0px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;background-color: #65dafd !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;}” el_class=”ankernavigation-light”][vc_column width=”1\/3″ el_class=”anker-first”][mk_fancy_title color=”#ffffff” size=”30″ margin_top=”29″ font_family=”none” align=”center”]Prenatal Karyotyping and Rapid Test<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=”1\/3″ el_class=”anker-middle”][mk_fancy_title color=”#ffffff” size=”30″ margin_top=”30″ margin_bottom=”19″ font_family=”none” align=”center”]Post\u00adnatal Karyotyping<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=”1\/3″ el_class=”anker-last”][mk_fancy_title color=”#ffffff” size=”30″ margin_top=”28″ font_family=”none” align=”center”]Forms & Sample Submission<\/a>[\/mk_fancy_title][\/vc_column][\/vc_row][mk_page_section min_height=”0″ padding_top=”0″ padding_bottom=”0″ section_id=”Pr\u00e4natale-Chromosomenanalyse-und-Interphase-FISH-Test” sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”120″ visibility=”hidden-sm”][mk_padding_divider size=”100″ visibility=”visible-sm”][\/vc_column][\/mk_page_section][mk_page_section section_id=”Prenatal-karyotyping” sidebar=”bb_sidemenu_widget”][vc_column width=”1\/3″][vc_row_inner][vc_column_inner][vc_empty_space][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/contentbilder-zytogen-diagnostik-490×846.jpg” image_size=”full” margin_bottom=”0″][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2015\/12\/blau-175×175.jpg” image_size=”full” align=”right” visibility=”hidden-sm” el_class=”padding30t”][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”2\/3″][vc_row_inner][vc_column_inner][vc_column_text el_class=”titlebox diagnostik-01″ css=”.vc_custom_1613726464119{margin-bottom: 0px !important;}”]\n

Prenatal Karyotyping and Rapid Test<\/h2>\n[\/vc_column_text][mk_padding_divider size=”25″ visibility=”visible-sm”][mk_padding_divider visibility=”hidden-sm”][vc_column_text el_class=”padding25lr” css=”.vc_custom_1613726474235{margin-bottom: 0px !important;}”]\n

On amniotic fluid cells after amniocentesis:<\/h4>\n

We accept 10 to 15 ml of amniotic fluid collected under sterile conditions for analysis. On each sample, a fluorescence in-situ hybridization (FISH) test will be performed and \u03b1-fetoprotein (AFP) will be determined.<\/p>\n

The result from the rapid test (numerical analysis of chromosomes 13, 18, 21, X and Y by FISH) can generally be supplied within 1 to 2 days, detailed karyotyping (numerical and structural) will take 9 to 14 days.[\/vc_column_text][vc_column_text el_class=”padding25lr” css=”.vc_custom_1613726482331{margin-bottom: 0px !important;}”]\n

On chorionic villi after chorionic villi sampling (CVS):<\/h4>\n

We need 15 to 20 mg of chorionic villi tissue for chromosome analysis or 30 to 40 mg of tissue for molecular genetic testing.<\/p>\n

The result of chromosome analysis from short-term culture is usually supplied within 24 hours and the result of long-term culture after about two weeks.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section][vc_column][vc_empty_space height=”100px” el_class=”v-spacer-100″][\/vc_column][\/mk_page_section][mk_page_section section_id=”postnatal-karyotyping” sidebar=”bb_sidemenu_widget”][vc_column width=”2\/3″][vc_row_inner][vc_column_inner][vc_column_text el_class=”titlebox diagnostik-01″ css=”.vc_custom_1613726491081{margin-bottom: 0px !important;}”]\n

Postnatal Karyotyping<\/h2>\n[\/vc_column_text][mk_padding_divider visibility=”hidden-sm”][mk_padding_divider size=”25″ visibility=”visible-sm”][vc_column_text el_class=”padding25lr” css=”.vc_custom_1613726499529{margin-bottom: 0px !important;}”]\n

On peripheral blood lymphocytes:<\/h4>\n

For the analysis, 2 to 10 ml whole blood should be collected under sterile conditions into lithium-heparin tubes and should be gently mixed.<\/p>\n

Culture establishment and analysis take 2 to 3 weeks, in urgent cases 5 to 9 days.[\/vc_column_text][vc_column_text el_class=”padding25lr” css=”.vc_custom_1613726506388{margin-bottom: 0px !important;}”]\n

On skin and tissue samples:<\/h4>\n

We can utilize skin biopsies, small tissue samples (1 qcm) or umbilical cord to grow fibroblast cultures for karyotyping. Upon collection under sterile conditions, the unfixed samples should be transported in sterile saline solution or special medium.<\/p>\n

The result of karyotyping will be supplied within about 4 weeks after receipt of samples.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][vc_column_inner width=”1\/6″][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/3″][vc_row_inner][vc_column_inner][vc_empty_space][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2015\/12\/left.jpg” image_size=”full” margin_bottom=”0″][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/180×287.jpg” image_size=”full” visibility=”hidden-sm” el_class=”padding30t”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section][vc_column][mk_padding_divider size=”100″ visibility=”hidden-sm”][mk_padding_divider size=”60″ visibility=”visible-sm”][\/vc_column][\/mk_page_section][mk_page_section][vc_column][vc_empty_space height=”100px” el_class=”v-spacer-100″][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column width=”2\/3″][vc_row_inner][vc_column_inner][vc_column_text el_class=”titlebox diagnostik-03″ css=”.vc_custom_1613726537755{margin-bottom: 0px !important;}”]\n

Contact<\/h2>\n[\/vc_column_text][mk_padding_divider visibility=”hidden-sm”][mk_padding_divider size=”25″ visibility=”visible-sm”][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=”1\/2″][vc_column_text el_class=”padding25lr” css=”.vc_custom_1613726556778{margin-bottom: 0px !important;}”]\n

Prof. Dr. rer. nat. Peter Burfeind<\/h4>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/2″][vc_column_text el_class=”padding25lr” css=”.vc_custom_1613726564522{margin-bottom: 0px !important;}”]Tel.: +49-551-39-67595<\/a>
\npeter.burfeind@med.uni-goettingen.de<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”1\/3″ offset=”vc_hidden-xs”][vc_row_inner][vc_column_inner][vc_empty_space][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/10\/diagnostik-03-287×180.jpg” align=”right”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section min_height=”0″ padding_top=”0″ padding_bottom=”0″ sidebar=”sidebar-1″][vc_column][vc_empty_space height=”100px”][\/vc_column][\/mk_page_section]\n<\/div>","protected":false},"excerpt":{"rendered":"

[mk_page_section bg_image=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/03\/LHA98622-Beratung-1900.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” min_height=”500″ full_width=”true” section_id=”header-bild” sidebar=”sidebar-1″][vc_column][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_empty_space height=”50px”][vc_column_text align=”center”] Cytogenetics [\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner][vc_column_text css=”.vc_custom_1535095981922{margin-bottom: 0px !important;}”]In classical cytogenetic diagnostics, we investigate chromosomes under the light microscope to detect anomalies affecting their number (aneuploidies) or their structure (e.g. inversions, translocations, duplications or deletions). This conventional method of chromosome analysis continues to be […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7667,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7912","page","type-page","status-publish","hentry"],"yoast_head":"\nCytogenetics - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/genetic-testing\/cytogenetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cytogenetics - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"[mk_page_section bg_image=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/03\/LHA98622-Beratung-1900.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” min_height=”500″ full_width=”true” section_id=”header-bild” sidebar=”sidebar-1″][vc_column][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_empty_space height=”50px”][vc_column_text align=”center”] Cytogenetics [\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner][vc_column_text css=”.vc_custom_1535095981922{margin-bottom: 0px !important;}”]In classical cytogenetic diagnostics, we investigate chromosomes under the light microscope to detect anomalies affecting their number (aneuploidies) or their structure (e.g. inversions, translocations, duplications or deletions). 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