{"id":7915,"date":"2016-03-24T10:13:26","date_gmt":"2016-03-24T09:13:26","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/en\/genetic-testing\/molekularzytogenetische-diagnostik\/"},"modified":"2024-10-10T14:26:12","modified_gmt":"2024-10-10T12:26:12","slug":"molecular-cytogenetics","status":"publish","type":"page","link":"https:\/\/www.humangenetik-umg.de\/en\/genetic-testing\/molecular-cytogenetics\/","title":{"rendered":"Molecular Cytogenetics"},"content":{"rendered":"
[mk_page_section bg_image=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/03\/LHA9970-molekularzytogenetik-1900.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” min_height=”500″ full_width=”true” section_id=”header-bild” sidebar=”sidebar-1″][vc_column][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_empty_space height=”50px”][vc_column_text align=”center”]\n

Molecular Cytogenetics
\n<\/span><\/h1>\n[\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner][vc_column_text]High-resolution molecular cytogenetic methods detect structural chromosomal changes that are too small to be visible by light microscope in conventional karyotyping. We use array CGH (array-based comparative genomic hybridization) analysis to search on the whole-genome level for submicroscopic chromosome aberrations such as microdeletions or duplications.<\/p>\n

Array CGH is a high-resolution genomic hybridization technique that compares patient DNA with a pooled, sex-specific DNA sample from a control group. Our laboratory uses the Human Genome CGH Microarray Kit 180 K (Agilent Technologies, USA). The generated CGH data are read by the high-resolution Agilent Microarray Scanner and extracted by the Agilent Feature Extraction Software. For interpretation of the data we use the current Agilent Cytogenomic Software. The theoretical resolution of the array platform we use is about 20 Kb. The copy number variations detected by array CGH analysis are then checked against relevant genomic variant databases as for example the ISCA <\/a>database and the Database of Genomic Variants<\/a>.[\/vc_column_text][vc_empty_space height=”50px”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][vc_row fullwidth=”true” fullwidth_content=”false” css=”.vc_custom_1476441189270{border-top-width: 0px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;background-color: #65dafd !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;}” el_class=”ankernavigation-light”][vc_column width=”1\/2″ css=”.vc_custom_1476441172773{border-right-width: 1px !important;border-left-width: 2px !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;}” el_class=”anker-first”][mk_fancy_title color=”#ffffff” size=”30″ margin_top=”25″ font_family=”none” align=”center”]Array CGH<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=”1\/2″ css=”.vc_custom_1476441158687{border-right-width: 2px !important;border-left-width: 1px !important;border-left-color: #ffffff !important;border-left-style: solid !important;border-right-color: #ffffff !important;border-right-style: solid !important;}” el_class=”anker-last”][mk_fancy_title color=”#ffffff” size=”30″ margin_top=”28″ font_family=”none” align=”center”]Forms & Sample Submission<\/a>[\/mk_fancy_title][\/vc_column][\/vc_row][mk_page_section min_height=”0″ sidebar=”sidebar-1″][vc_column][mk_padding_divider size=”200″ visibility=”hidden-sm”][mk_padding_divider visibility=”visible-sm”][\/vc_column][\/mk_page_section][mk_page_section section_id=”array-cgh” sidebar=”bb_sidemenu_widget”][vc_column width=”1\/3″][vc_row_inner][vc_column_inner][vc_empty_space][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/contentbilder-molekularzytogen-diagnostik-490×846.jpg” image_size=”full” margin_bottom=”0″][vc_empty_space][mk_image src=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/10\/diagnostik-01-175×175.jpg” image_size=”full” align=”right” visibility=”hidden-sm” el_class=”padding30t”][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=”2\/3″][vc_row_inner el_id=”array-CGH”][vc_column_inner][vc_column_text el_class=”titlebox diagnostik-01″ css=”.vc_custom_1613725657947{margin-bottom: 0px !important;}”]\n

Array CGH<\/h2>\n[\/vc_column_text][mk_padding_divider size=”25″ visibility=”visible-sm”][mk_padding_divider visibility=”hidden-sm”][vc_column_text el_class=”padding25lr” css=”.vc_custom_1613725666049{margin-bottom: 0px !important;}”]Array CGH analysis is mostly applied to find the genetic cause in patients with mental retardation and\/or unclear retardation\/malformation syndromes.[\/vc_column_text][mk_custom_list icon_color=”#95c8d9″ el_class=”custom-list padding25lr”]Specifically, it is used to diagnose patients with:<\/p>\n