{"id":8007,"date":"2016-10-24T15:45:22","date_gmt":"2016-10-24T13:45:22","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/en\/research\/molekulare-entwicklungsgenetik\/"},"modified":"2025-10-23T15:14:53","modified_gmt":"2025-10-23T13:14:53","slug":"molecular-developmental-genetics","status":"publish","type":"page","link":"https:\/\/www.humangenetik-umg.de\/en\/research\/molecular-developmental-genetics\/","title":{"rendered":"Molecular Developmental Genetics"},"content":{"rendered":"<div class=\"wpb-content-wrapper\">[vc_row attached=&#8221;true&#8221; padding=&#8221;2&#8243;][vc_column][vc_empty_space height=&#8221;60&#8243;][mk_padding_divider size=&#8221;32&#8243;][vc_column_text align=&#8221;center&#8221;]\n<h1 style=\"text-align: center;\"><span style=\"color: #ff9900;\">Section of<br \/>\nMolecular Developmental Genetics<\/span><\/h1>\n[\/vc_column_text][vc_empty_space][vc_row_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;.vc_custom_1702303005767{margin-bottom: 0px !important;}&#8221;]\n<p style=\"text-align: left;\"><strong>Dr. rer. nat. Yehan Bian<\/strong><br \/>\nPostDoc<br \/>\n<a href=\"mailto:yehan.bian@med.uni-goettingen.de\">yehan.bian@med.uni-goettingen.de<\/a><\/p>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;.vc_custom_1761224699728{margin-bottom: 0px !important;}&#8221;]\n<p style=\"text-align: left;\"><strong>PD Dr. rer. nat. Anja Uhmann<br \/>\n<\/strong>Head of lab<br \/>\n<a href=\"mailto:auhmann@gwdg.de\">auhmann@gwdg.de<\/a><br \/>\n<a href=\"mailto:anja.uhmann@med.uni-goettingen.de\">anja.uhmann@med.uni-goettingen.de<\/a><\/p>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;.vc_custom_1656422571451{margin-bottom: 0px !important;}&#8221;]\n<p style=\"text-align: left;\"><strong>Prof. Dr. med. Heidi Hahn<br \/>\n<\/strong>Group leader<br \/>\n<a href=\"mailto:hhahn@gwdg.de\">hhahn@gwdg.de<\/a><\/p>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=&#8221;80&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/6&#8243;][vc_icon icon_fontawesome=&#8221;fa fa-file-pdf-o&#8221; color=&#8221;custom&#8221; size=&#8221;xl&#8221; align=&#8221;center&#8221; custom_color=&#8221;#ff9900&#8243;][\/vc_column_inner][vc_column_inner width=&#8221;5\/6&#8243;][vc_column_text css=&#8221;.vc_custom_1761224726465{margin-bottom: 0px !important;}&#8221;]<a href=\"https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2021\/08\/cv_heidi-hahn-2021.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">CV Prof. Heidi Hahn<\/a><br \/>\n<a href=\"https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2025\/10\/cv_pd_-dr_anja-uhmann.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">CV PD Dr. Anja Uhmann<\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=&#8221;60px&#8221;][\/vc_column][\/vc_row][vc_row fullwidth=&#8221;true&#8221; fullwidth_content=&#8221;false&#8221; css=&#8221;.vc_custom_1473753570382{border-top-width: 0px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;background-color: #ff9900 !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;}&#8221; el_class=&#8221;ankernavigation-dark&#8221;][vc_column width=&#8221;1\/2&#8243; el_class=&#8221;anker-middle&#8221;][mk_fancy_title color=&#8221;#ffffff&#8221; size=&#8221;30&#8243; margin_top=&#8221;28&#8243; margin_bottom=&#8221;12&#8243; font_family=&#8221;none&#8221; align=&#8221;center&#8221; animation=&#8221;scale-up&#8221;]<a href=\"#projects\">Projects<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=&#8221;1\/2&#8243; el_class=&#8221;anker-middle&#8221;][mk_fancy_title color=&#8221;#ffffff&#8221; size=&#8221;30&#8243; margin_top=&#8221;28&#8243; margin_bottom=&#8221;12&#8243; font_family=&#8221;none&#8221; align=&#8221;center&#8221; animation=&#8221;scale-up&#8221;]<a href=\"#publications\">Publications<\/a>[\/mk_fancy_title][\/vc_column][\/vc_row][mk_page_section min_height=&#8221;0&#8243; padding_top=&#8221;0&#8243; padding_bottom=&#8221;0&#8243; section_id=&#8221;projects&#8221; sidebar=&#8221;sidebar-1&#8243;][vc_column][vc_row_inner][vc_column_inner][vc_empty_space height=&#8221;100&#8243;][vc_column_text]\n<h2 style=\"text-align: center;\"><span style=\"color: #ff9900;\">Projects<\/span><\/h2>\n[\/vc_column_text][mk_padding_divider size=&#8221;32&#8243;][mk_custom_list icon_color=&#8221;#ff9900&#8243; el_class=&#8221;custom-list&#8221;]\n<ul>\n<li>\n<h3><a href=\"#interactions-hedgehog\">Interactions of Hedgehog and Ras signaling pathways in rhabdomyosarcoma<\/a><\/h3>\n<\/li>\n<li>\n<h3><a href=\"#wnt5a\">Role of Wnt5a in rhabdomyosarcoma<\/a><\/h3>\n<\/li>\n<li>\n<h3><a href=\"#pituitary-gland\">The role of the Hedgehog signaling cascade in the adult pituitary gland and in the development of pituitary adenoma<\/a><\/h3>\n<\/li>\n<li>\n<h3><a href=\"#stem-cells\">Adult stem cells of skin and their role in the development of skin cancer<\/a><\/h3>\n<\/li>\n<\/ul>\n[\/mk_custom_list][mk_padding_divider size=&#8221;32&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section section_id=&#8221;interactions-hedgehog&#8221; sidebar=&#8221;sidebar-1&#8243;][vc_column width=&#8221;2\/3&#8243;][vc_empty_space height=&#8221;30&#8243;][vc_column_text el_class=&#8221;yellow-background&#8221; css=&#8221;.vc_custom_1622706041314{margin-bottom: 0px !important;}&#8221;]\n<h3>Interactions of Hedgehog and Ras signaling pathways in rhabdomyosarcoma<\/h3>\n[\/vc_column_text][vc_empty_space][vc_row_inner][vc_column_inner][vc_column_text css=&#8221;.vc_custom_1656422583442{margin-bottom: 0px !important;}&#8221;]Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Recently, we identified aberrant Hedgehog (Hh) pathway activation in subgroups of RMS in both human and mice. Frequently, RMS also harbor activating Ras mutations that can occur in all 3 Ras genes. Since Ras can modulate Hh signaling activity, we analyze the effects of all 3 oncogenic Ras mutations on Hh-associated tumor growth using cell lines and mouse models.<br \/>\n(Heidi Hahn)[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][mk_padding_divider size=&#8221;32&#8243;][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_empty_space height=&#8221;32&#8243;][mk_padding_divider size=&#8221;70&#8243; visibility=&#8221;hidden-sm&#8221;][mk_image src=&#8221;https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/contentbilder-287-180.jpg&#8221; image_width=&#8221;287&#8243; image_height=&#8221;180&#8243; visibility=&#8221;hidden-sm&#8221;][\/vc_column][\/mk_page_section][mk_page_section section_id=&#8221;wnt5a&#8221; sidebar=&#8221;bb_sidemenu_widget&#8221;][vc_column width=&#8221;1\/3&#8243;][vc_empty_space height=&#8221;32&#8243;][mk_padding_divider size=&#8221;70&#8243; visibility=&#8221;hidden-sm&#8221;][mk_image src=&#8221;https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/contentbilder-287-180.jpg&#8221; image_width=&#8221;287&#8243; image_height=&#8221;180&#8243; align=&#8221;right&#8221; visibility=&#8221;hidden-sm&#8221;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_empty_space height=&#8221;30&#8243;][vc_column_text el_class=&#8221;yellow-background&#8221; css=&#8221;.vc_custom_1622706084028{margin-bottom: 0px !important;}&#8221;]\n<h3>Role of Wnt5a in rhabdomyosarcoma<\/h3>\n[\/vc_column_text][vc_empty_space height=&#8221;20px&#8221;][vc_row_inner][vc_column_inner][vc_column_text css=&#8221;.vc_custom_1656422594075{margin-bottom: 0px !important;}&#8221;]Rhabdomyosarcoma (RMS) develops from skeletal muscle cells that have failed to fully differentiate and is the most common soft tissue sarcoma in children. Although Wnt signaling plays an important role in muscle development, only few data have been published with respect to RMS. We analyze the role of Wnt5a, which is an important component of the \u00df-catenin-independent Wnt signaling pathway in RMS using cell lines and mouse models.<br \/>\n(Heidi Hahn)[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][mk_padding_divider size=&#8221;32&#8243;][\/vc_column][\/mk_page_section][mk_page_section section_id=&#8221;pituitary-gland&#8221; sidebar=&#8221;bb_sidemenu_widget&#8221;][vc_column width=&#8221;2\/3&#8243;][vc_empty_space height=&#8221;30&#8243;][vc_column_text el_class=&#8221;yellow-background&#8221; css=&#8221;.vc_custom_1622706221179{margin-bottom: 0px !important;}&#8221;]\n<h3>The role of the Hedgehog signaling cascade in the adult pituitary gland and in the development of pituitary adenoma<\/h3>\n[\/vc_column_text][vc_empty_space][vc_row_inner][vc_column_inner][vc_column_text css=&#8221;.vc_custom_1668091667792{margin-bottom: 0px !important;}&#8221;]The Hedgehog (HH) signaling pathway plays an essential role during the development of the pituitary gland, which represents a gland with superior function in the neuroendocrine system. However the knowledge about the function of the HH signaling cascade in the adult pituitary gland and in pituitary adenoma formation is sparse. By using mouse models and human tissue samples we are investigating how HH signaling influences the development of hormone expressing cells, the hormone regulation of the gland and the development of adenoma. Additionally we are validating if Smoothened inhibitors are potential treatment options against pituitary tumors.<br \/>\n(Anja Uhmann \/ Yehan Bian)[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][mk_padding_divider size=&#8221;32&#8243;][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_empty_space height=&#8221;32&#8243;][mk_padding_divider size=&#8221;70&#8243; visibility=&#8221;hidden-sm&#8221;][mk_image src=&#8221;https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/contentbilder-287-180.jpg&#8221; image_width=&#8221;287&#8243; image_height=&#8221;180&#8243; visibility=&#8221;hidden-sm&#8221;][\/vc_column][\/mk_page_section][mk_page_section section_id=&#8221;stem-cells&#8221; sidebar=&#8221;bb_sidemenu_widget&#8221;][vc_column width=&#8221;1\/3&#8243;][vc_empty_space height=&#8221;32&#8243;][mk_padding_divider size=&#8221;70&#8243; visibility=&#8221;hidden-sm&#8221;][mk_image src=&#8221;https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2016\/07\/contentbilder-287-180.jpg&#8221; image_width=&#8221;287&#8243; image_height=&#8221;180&#8243; align=&#8221;right&#8221; visibility=&#8221;hidden-sm&#8221;][\/vc_column][vc_column width=&#8221;2\/3&#8243;][vc_empty_space height=&#8221;30&#8243;][vc_column_text el_class=&#8221;yellow-background&#8221; css=&#8221;.vc_custom_1622706468003{margin-bottom: 0px !important;}&#8221;]\n<h3>Adult stem cells of skin and their role in the development of skin cancer<\/h3>\n[\/vc_column_text][vc_empty_space height=&#8221;20px&#8221;][vc_row_inner][vc_column_inner][vc_column_text css=&#8221;.vc_custom_1668091680598{margin-bottom: 0px !important;}&#8221;]Adult stem cells of the skin are essential for the natural regeneration of the skin and wound healing. However they also play a crucial role in the formation of skin cancer. In this project we are using mouse models and human skin samples to analyze a newly described stem cell-like cell population of the skin and its function in the normal skin homoeostasis as well as in the development of skin cancer.<br \/>\n(Anja Uhmann \/ Yehan Bian)[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section min_height=&#8221;0&#8243; padding_top=&#8221;0&#8243; padding_bottom=&#8221;0&#8243; section_id=&#8221;publications&#8221; sidebar=&#8221;sidebar-1&#8243;][vc_column][vc_empty_space height=&#8221;100&#8243;][vc_column_text]\n<h2 style=\"text-align: center;\"><span style=\"color: #ff9900;\">Publications Hahn Research Group<br \/>\n<\/span><\/h2>\n[\/vc_column_text][mk_padding_divider][\/vc_column][\/mk_page_section][mk_page_section min_height=&#8221;0&#8243; padding_top=&#8221;0&#8243; padding_bottom=&#8221;0&#8243; section_id=&#8221;anker-1&#8243; sidebar=&#8221;sidebar-1&#8243;][vc_column][mk_padding_divider size=&#8221;20&#8243;][\/vc_column][\/mk_page_section][vc_row fullwidth=&#8221;true&#8221; fullwidth_content=&#8221;false&#8221; css=&#8221;.vc_custom_1473753612485{border-top-width: 0px !important;border-right-width: 0px !important;border-bottom-width: 0px !important;background-color: #ff9900 !important;border-right-color: #ffffff !important;border-right-style: solid !important;border-top-color: #ffffff !important;border-top-style: solid !important;border-bottom-color: #ffffff !important;border-bottom-style: solid !important;}&#8221; el_class=&#8221;ankernavigation-dark&#8221;][vc_column width=&#8221;1\/4&#8243; el_class=&#8221;anker-first&#8221;][\/vc_column][vc_column width=&#8221;1\/4&#8243; el_class=&#8221;anker-middle&#8221;][mk_fancy_title color=&#8221;#ffffff&#8221; size=&#8221;30&#8243; margin_top=&#8221;28&#8243; margin_bottom=&#8221;12&#8243; font_family=&#8221;none&#8221; align=&#8221;center&#8221; animation=&#8221;scale-up&#8221;]<a href=\"#2021\">2021 to present<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=&#8221;1\/4&#8243; el_class=&#8221;anker-middle&#8221;][mk_fancy_title color=&#8221;#ffffff&#8221; size=&#8221;30&#8243; margin_top=&#8221;28&#8243; margin_bottom=&#8221;12&#8243; font_family=&#8221;none&#8221; align=&#8221;center&#8221; animation=&#8221;scale-up&#8221;]<a href=\"#2020\">2020 and before<\/a>[\/mk_fancy_title][\/vc_column][vc_column width=&#8221;1\/4&#8243; el_class=&#8221;anker-last&#8221;][\/vc_column][\/vc_row][mk_page_section min_height=&#8221;0&#8243; padding_top=&#8221;0&#8243; padding_bottom=&#8221;0&#8243; section_id=&#8221;2021&#8243; sidebar=&#8221;sidebar-1&#8243;][vc_column][mk_padding_divider size=&#8221;120&#8243;][\/vc_column][\/mk_page_section][mk_page_section sidebar=&#8221;sidebar-1&#8243;][vc_column][vc_row_inner][vc_column_inner][vc_column_text el_class=&#8221;titlebox forschung-02&#8243; css=&#8221;.vc_custom_1761224952888{margin-bottom: 0px !important;}&#8221;]<span class=\"title-after\">2021 to present<\/span>[\/vc_column_text][mk_padding_divider size=&#8221;25&#8243; visibility=&#8221;visible-sm&#8221;][mk_padding_divider visibility=&#8221;hidden-sm&#8221;][vc_column_text el_class=&#8221;padding25lr publikationen&#8221; css=&#8221;.vc_custom_1761224986584{margin-bottom: 0px !important;}&#8221;]<a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40991146\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Isolation, Culture, and Analyses of Keratinocytes, Fibroblasts, and Hair Follicles from Normal Human Skin and Cancer-Associated Fibroblasts from Skin Tumors<\/b><br \/>\n<\/a>Lorenz VN, Uhmann A<br \/>\n<em>Methods Mol Biol. <\/em>2025 Sep 25. doi: 10.1007\/7651_2025_663. Online ahead of print.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40059030\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Triclosan exacerbates atopic dermatitis in mouse models via thymic stromal lymphopoietin<\/b><br \/>\n<\/a>Schuppe MC, Porebski P, Hahn KK, Liao K, Uhmann A, Braun A, Dasari P, Sch\u00f6n MP, Buhl T<br \/>\n<em>J Dermatol Sci.<\/em> 2025 Apr;118(1):1-8. doi: 10.1016\/j.jdermsci.2025.02.007<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39905055\" target=\"_blank\" rel=\"noopener noreferrer\"><b>CD4 expression controls epidermal stem cell balance<\/b><br \/>\n<\/a>Brandes N, Hahn H, Uhmann A<br \/>\n<em>Sci Rep.<\/em> 2025 Feb 4;15(1):4185. doi: 10.1038\/s41598-025-87915-7.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37582359\" target=\"_blank\" rel=\"noopener noreferrer\"><b>AXIN1 bi-allelic variants disrupting the C-terminal DIX domain cause craniometadiaphyseal osteosclerosis with hip dysplasia<\/b><br \/>\n<\/a>Terhal P, Venhuizen AJ, Lessel D, Tan WH, Alswaid A, Gr\u00fcn R, Alzaidan HI, von Kroge S, Ragab N, Hempel M, Kubisch C, Novais E, Cristobal A, Tripolszki K, Bauer P, Fischer-Zirnsak B, Nievelstein RAJ, van Dijk A, Nikkels P, Oheim R, Hahn H, Bertoli-Avella A, Maurice MM, Kornak U<br \/>\n<em>Am J Hum Genet<\/em> 2023 Aug 9:S0002-9297(23)00251-3. doi: 10.1016\/j.ajhg.2023.07.011. Epub ahead of print.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37476499\" target=\"_blank\" rel=\"noopener noreferrer\"><b> The hidden hedgehog of the pituitary: hedgehog signaling in development, adulthood and disease of the hypothalamic-pituitary axis <\/b><br \/>\n<\/a> Bian Y, Hahn H, Uhmann A<br \/>\n<em> Front Endocrinol (Lausanne)<\/em> 2023 Jul 5;14:1219018. doi: 10.3389\/fendo.2023.1219018.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35796028\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Tumor suppressive functions of WNT5A in rhabdomyosarcoma<\/b><\/a><br \/>\nRagab N, Bauer J, Uhmann A, Marx A, Hahn H, Simon-Keller K<br \/>\n<em>Int J Oncol<\/em> 2022 Sep;61(3):102. doi: 10.3892\/ijo.2022.5392.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34172934\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Context-dependent modulation of aggressiveness of pediatric tumors by individual oncogenic RAS isoforms<\/b><\/a><br \/>\nBauer J, Cuvelier N, Ragab N, Simon-Keller K, Nitzki F, Geyer N, Botermann DS, Elmer DP, Rosenberger A, Rando TA, Biressi S, Fagin JA, Saur D, Dullin C, Schildhaus HU, Schulz-Schaeffer W, Aberger F, Uhmann A, Hahn H<br \/>\n<em>Oncogene<\/em>. 2021 Aug;40(31):4955-4966. doi: 10.1038\/s41388-021-01904-4.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33480359\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Hedgehog signaling in endocrine and folliculo-stellate cells of the adult pituitary<\/b><\/a><br \/>\nBotermann DS, Brandes N, Frommhold A, He\u00df I, Wolff A, Zibat A, Hahn H, Buslei R, Uhmann A<br \/>\n<em>J Endocrinol.<\/em> 2021 Mar;248(3):303-316. doi: 10.1530\/JOE-20-0388<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33637728\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Mechanochemical control of epidermal stem cell divisions by B-plexins<\/b><\/a><br \/>\nJiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fern\u00e1ndez-Baldovinos J, Zhou L, H\u00f6\u00df C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Gr\u00f6ne HJ, Graumann PL, Niessen CM, Offermanns S, Wickstr\u00f6m SA, Worzfeld T<br \/>\n<em>Nat Commun.<\/em> 2021 Feb 26;12(1):1308. doi: 10.1038\/s41467-021-21513-9.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34948179\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Oncogenic NRAS Accelerates Rhabdomyosarcoma Formation When Occurring within a Specific Time Frame during Tumor Development in Mice<\/b><\/a><br \/>\nRagab N, Bauer J, Botermann DS, Uhmann A, Hahn H<br \/>\n<em>Int J Mol Sci.<\/em> 2021 Dec 13;22(24):13377. doi: 10.3390\/ijms222413377.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33024317\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Heterozygous truncating variants in SUFU cause congenital ocular motor apraxia<\/b><\/a><br \/>\nSchr\u00f6der S, Li Y, Yigit G, Altm\u00fcller J, Bader I, Bevot A, Biskup S, Dreha-Kulaczewski S, Christoph Korenke G, Kottke R, Mayr JA, Preisel M, Toelle SP, Wente-Schulz S, Wortmann SB, Hahn H, Boltshauser E, Uhmann A, Wollnik B, Brockmann K<br \/>\n<em>Genet Med.<\/em> 2021 Feb;23(2):341-351. doi: 10.1038\/s41436-020-00979-w. Epub 2020 Oct 7.<br \/>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section min_height=&#8221;0&#8243; padding_top=&#8221;0&#8243; padding_bottom=&#8221;0&#8243; section_id=&#8221;2020&#8243; sidebar=&#8221;sidebar-1&#8243;][vc_column][mk_padding_divider size=&#8221;120&#8243;][\/vc_column][\/mk_page_section][mk_page_section sidebar=&#8221;sidebar-1&#8243;][vc_column][vc_row_inner][vc_column_inner][vc_column_text el_class=&#8221;titlebox forschung-02&#8243; css=&#8221;.vc_custom_1761224757332{margin-bottom: 0px !important;}&#8221;]<span class=\"title-after\">2020 and before<\/span>[\/vc_column_text][mk_padding_divider visibility=&#8221;hidden-sm&#8221;][mk_padding_divider size=&#8221;25&#8243; visibility=&#8221;visible-sm&#8221;][vc_empty_space][vc_column_text el_class=&#8221;padding25lr publikationen&#8221; css=&#8221;.vc_custom_1761224841067{margin-bottom: 0px !important;}&#8221;]<a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31987884\" target=\"_blank\" rel=\"noopener noreferrer\"><b>WIF1 Suppresses the Generation of Suprabasal Cells in Acanthotic Skin and Growth of Basal Cell Carcinomas upon Forced Overexpression<\/b><\/a><br \/>\nBecker M, Bauer J, Pyczek J, K\u00f6nig S, M\u00fcllen A, Rabe H, Sch\u00f6n MP, Uhmann A, Hahn H<br \/>\n<em>J Invest Dermatol<\/em> 2020, 140(8):1556-1565.e11, doi: 10.1016\/j.jid.2019.11.030<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33291515\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice<\/b><\/a><br \/>\nBrandes N, Mitkovska SH, Botermann DS, Maurer W, M\u00fcllen A, Scheile H, Zabel S, Frommhold A, He\u00df I, Hahn H, Uhmann A<br \/>\n<em>Int J Mol Sci<\/em> 2020, 21(23):9295, doi: 10.3390\/ijms21239295<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30857197\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model<\/b><\/a><br \/>\nLinder B, Weirauch U, Ewe A, Uhmann A, Seifert V, Mittelbronn M, Harter PN, Aigner A, K\u00f6gel D<br \/>\n<em>Cancers<\/em> 2019, 11(3): -, doi: 10.3390\/cancers11030333<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31867038\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis<\/b><\/a><br \/>\nPyczek J, Khizanishvili N, Kuzyakova M, Zabel S, Bauer J, Nitzki F, Emmert S, Sch\u00f6n MP, Boukamp P, Schildhaus HU, Uhmann A, Hahn H<br \/>\n<em>Front Genet<\/em> 2019, 10: 1185, doi: 10.3389\/fgene.2019.01185<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31222885\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Insights into pediatric rhabdomyosarcoma research: Challenges and goals<\/b><\/a><br \/>\nYohe ME, Heske CM, Stewart E, Adamson PC, Ahmed N, Antonescu CR, Chen E, Collins N, Ehrlich A, Galindo RL, Gryder BE, Hahn H, Hammond S, Hatley ME, Hawkins DS, Hayes MN, Hayes-Jordan A, Helman LJ, Hettmer S, Ignatius MS, Keller C, Khan J, Kirsch DG, Linardic CM, Lupo PJ, Rota R, Shern JF, Shipley J, Sindiri S, Tapscott SJ, Vakoc CR, Wexler LH, Langenau DM<br \/>\n<em>Pediatr Blood Cancer <\/em>2019, June 21: e27869, doi: 10.1002\/pbc.27869<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30319965\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors<\/b><\/a><br \/>\nGeyer N, Ridzewski R, Bauer J, Kuzyakova M, Dittmann K, Dullin C, Rosenberger A, Schildhaus HU, Uhmann A, Fulda S, Hahn H<br \/>\n<em>Front Oncol<\/em> 2018, 8: 396, doi: 10.3389\/fonc.2018.00396<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30568936\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Canonical WNT\/\u03b2-Catenin Signaling Plays a Subordinate Role in Rhabdomyosarcomas<\/b><\/a><br \/>\nRagab N, Viehweger F, Bauer J, Geyer N, Yang M, Seils A, Belharazem D, Brembeck FH, Schildhaus HU, Marx A, Hahn H, Simon-Keller K<br \/>\n<em>Front Pediatr<\/em> 2018, 6: 378, doi: 10.3389\/fped.2018.00378<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29276753\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response<\/b><\/a><br \/>\nWestendorp BF, B\u00fcller NVJA, Karpus ON, van Dop WA, Koster J, Versteeg R, Koelink PJ, Snel CY, Meisner S, Roelofs JJTH, Uhmann A, Ver Loren van Themaat E, Heijmans J, Hahn H, Muncan V, Wildenberg ME, van den Brink GR<br \/>\n<em>Cell Mol Gastroenterol Hepatol<\/em> 2018, 5(1): 67-82.e1, doi: 10.1016\/j.jcmgh.2017.08.004<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28881358\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands<\/b><\/a><br \/>\nAlmaz\u00e1n-Moga A, Zarzosa P, Molist C, Velasco P, Pyczek J, Simon-Keller K, Giralt I, Vidal I, Navarro N, Segura MF, Soriano A, Navarro S, Tirado OM, Ferreres JC, Santamaria A, Rota R, Hahn H, S\u00e1nchez de Toledo J, Roma J, Gallego S<br \/>\n<em>Br J Cancer <\/em> 2017 Sep 7. doi: 10.1038\/bjc.2017.305. [Epub ahead of print]\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28807898\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3\/LHX4 pituitary embryonic precursors<\/b><\/a><br \/>\nCarreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP<br \/>\n<em>Development<\/em> 2017 Sep 15;144(18):3289-3302. doi: 10.1242\/dev.153387<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27965462\" target=\"_blank\" rel=\"noopener noreferrer\"><b>LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma<\/b><\/a><br \/>\nDr\u00e4ger J, Simon-Keller K, Pukrop T, Klemm F, Wilting J, Sticht C, Dittmann K, Schulz M, Leuschner I, Marx A, Hahn H<br \/>\n<em>Oncotarget<\/em> 2017 Jan 10;8(2):3259-3273. doi: 10.18632\/oncotarget.13887<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27666792\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Hedgehog Controls Quiescence and Activation of Neural Stem Cells in the Adult Ventricular-Subventricular Zone<\/b><\/a><br \/>\nDaynac M; Faure H; Mouthon MA; Gauthier L; Hahn H; Traiffort E; Boussin FD; Ruat M<br \/>\n<em>Stem Cell Reports<\/em> 2016 Oct 11 Vol. 7, 1-14<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27521572\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs<\/b><\/a><br \/>\nMeister MT; Boedicker C; Graab U; Hugle M; Hahn H; Klingebiel T; Fulda S<br \/>\n<em>Cancer Letter<\/em> 2016 Aug 10;381(2):287-295.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27109116\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Hedgehog signaling activation induces stem cell proliferation and hormone release in the adult pituitary gland<\/b><\/a><br \/>\nPyczek J; Buslei R; Schult D; H\u00f6lsken A; Buchfelder M; He\u00df I; Hahn H; Uhmann A<br \/>\n<em>Scientific Report<\/em> 2016 Apr 25;6:24928. doi: 10.1038\/srep24928.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26387541\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Hedgehog\/Patched-associated rhabdomyosarcoma formation from Delta1-expressing mesodermal cells<\/b><\/a><br \/>\nNitzki F; Cuvelier N; Dr\u00e4ger J; Schneider A; Braun T; Hahn H.<br \/>\n<em>Oncogene <\/em>2016 Jun 2;35(22):2923-31. doi: 10.1038\/onc.2015.346. Epub 2015 Sep 21.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26126827\" target=\"_blank\" rel=\"noopener noreferrer\"><b>A functional and putative physiological role of calcitriol in Patched\/Smoothened interaction<\/b><\/a><br \/>\nLinder B; Weber S; Dittmann K; Adamski J; Hahn H; Uhmann A<br \/>\n<em>J Biol Chem<\/em>. 2015 Jun 30. pii: jbc.M115.646141.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26106586\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Hedgehog inhibitors in rhabdomyosarcoma: a comparison of 4 compounds and responsiveness of 4 cell lines<\/b><\/a><br \/>\nRidzewski R; Rettberg D; Dittmann K; Cuvelier N; Fulda S; Hahn H<br \/>\n<em>Front Oncol.<\/em> 2015 Jun 8;5:130. doi: 10.3389\/fonc. 2015.00130.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26157704\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Oncogenic RAS mutants confer resistance of rhabdomyosarcoma cells to oxidative stress-induced ferroptotic cell death<\/b><\/a><br \/>\nSchott C; Graab, U; Cuvelier N; Hahn, H; Fulda S<br \/>\n<em>Front Oncol.<\/em> 2015 Jun 22;5:131. doi: 10.3389\/fonc.2015.00131.<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25823816\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy<\/b><\/a><br \/>\nNitzki F; Tolosa EJ; Cuvelier N; Frommhold A; Salinas-Riester G; Johnsen SA; Fernandez-Zapico ME; Hahn H.<br \/>\n<em>Oncotarget <\/em>2015 Apr 20;6(11):9113-24<\/p>\n<p><a style=\"text-decoration: none;\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25749378\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma<\/b><\/a><br \/>\nGraab U; Hahn H; Fulda S<br \/>\n<em>Oncotarget <\/em>2015 Apr 20;6(11):8722-35<\/p>\n<p><b>Genetic activation of Hedgehog signaling promotes adult neural stem cell symmetric divisions in the subventricular zone<\/b><br \/>\nFerent J; Cochard L; Hahn H; Ruat M; Traiffort E<br \/>\n<em>Stem Cell Reports.<\/em> 2014 Aug 12;3(2):312-23<\/p>\n<p><b>Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice<\/b><br \/>\nK\u00f6nig S; Nitzki F; Uhmann A; Dittmann K; Theiss J; Herrmann M; Reichardt HM; Schwendener R; Pukrop T; Schulz-Schaeffer W; Hahn H<br \/>\n<em>PLoS One<\/em>. 2014 Apr 1;9(4):e93555<\/p>\n<p><b>DMBA\/TPA treatment is necessary for BCC formation from Patched deficient epidermal cells in <em>Ptch<sup>flox\/flox<\/sup>CD4Cre<sup>+\/-<\/sup><\/em> mice<\/b><br \/>\nUhmann A; He\u00df I; Frommhold A; K\u00f6nig S; Zabel S; Nitzki F; Dittmann K; L\u00fchder F; Christiansen H; Reifenberger J; Schulz-Schaeffer W; Hahn H<br \/>\n<em>J Invest Dermatol. <\/em>2014 Oct;134(10):2620-9<\/p>\n<p><b>Interaction of Hedgehog and Vitamin D Signaling pathways in Basal Cell Carcinomas<\/b><br \/>\nAlbert B and Hahn H<br \/>\nChapter in \u201cSunlight, Vitamin D and Skin Cancer, Second Edition\u201d, edited by J\u00f6rg Reichrath 2014, <em>Adv Exp Med Biol.<\/em> 2014;810:329-41.<\/p>\n<p><b>Inactivation of patched1 in chondrocytes causes spinal ankylosis without inflammation<\/b><br \/>\nDittmann K; Wuelling W; Uhmann A; Nitzki F; Dullin C; Syrbe U; Sieper J; Hahn H; Schweyer S; Vortkamp A; Wienands J<br \/>\n<em>Arthritis Rheumatol.<\/em> 2014 Apr;66(4):831-40<\/p>\n<p><b>Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1\/2 agonist Pam<sub>3<\/sub>CSK<sub>4<\/sub> (BLP)<\/b><br \/>\nK\u00f6nig S; Regen T; Dittmann K; Engelke M; Wienands J; Schwendener R; Hanisch UK; Pukrop T; Hahn H<br \/>\n<em>Cancer Immunol Immunother.<\/em> 2013 Oct;62(10):1587-97<\/p>\n<p><b>The Hedgehog receptor patched1 in T cells is dispensable for adaptive immunity in mice<\/b><br \/>\nMichel KD; Uhmann A; Dressel R; van den Brandt J; Hahn H; Reichardt HM<br \/>\n<em>PLOS ONE <\/em>1 April 2013 Volume 8 Issue 4 e61034<\/p>\n<p><b>Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine esophagus<\/b><br \/>\nvan Dop WA; Rosekrans SL; Uhmann A; Jaks V; Offerhaus GJ; van den Bergh Weerman MA; Kasper M; Heijmans J; Hardwick JC; Verspaget HW; Hommes DW; Toftg\u00e5rd R; Hahn H; van den Brink GR<br \/>\n<em>GUT<\/em> 2013 Mar;62(3):348-5<\/p>\n<p><b>Inactivation of patched1 in mice leads to development of gastrointestinal stromal-like tumors that express pdgfr\u03b1 but not kit<\/b><br \/>\nPelczar P; Zibat Z; van Dop WA; Heijmans J; Bleckmann A; Gruber W; Nitzki F; Uhmann A; Guijarro MV; Hernando E; Dittmann K; Wienands J; Dressel R; Wojnowski L; Binder C; Taguchi T; Beissbarth T; Hogendoorn PCW; Antonescu CR; Rubin BP; Schulz-Schaeffer W; Aberger F; van den Brink GR; Hahn H<br \/>\n<em>Gastroenterology <\/em>2013 Jan;144(1):134-144.e6.<\/p>\n<p><b>PI3K Inhibition Enhances Doxorubicin-Induced Apoptosis in Sarcoma Cells<\/b><br \/>\nMarklein D, Graab U, Naumann I, Yan T, Ridzewski R, Nitzki F, Rosenberger A, Dittmann K, Wienands J, Wojnowski L, Fulda S, Hahn H<br \/>\n<em>PLoS One<\/em> 2012;7(12):e52898.<\/p>\n<p><b>Patched knockout mouse models of Basal Cell Carcinoma<\/b><br \/>\nNitzki F; Becker M; Frommhold A; Schulz-Schaeffer W; Hahn H<br \/>\n<em>J Skin Cancer<\/em> 2012;2012:907543.<\/p>\n<p><b>Calcitriol inhibits Hedgehog signaling and induces vitamin D receptor-signaling and differentiation in the patched mouse model of embryonal rhabdomyosarcoma<\/b><br \/>\nUhmann A; Niemann H; Lammering B; Henkel C; Hess I; Rosenberger A; Dullin C; Schraepler A; Schulz-Schaeffer W; Hahn H<br \/>\n<em>Sarcoma <\/em>2012;2012:357040.<\/p>\n<p><b>Antitumoral effects of Calcitriol in Basal Cell Carcinoma involve inhibition of Hedgehog Signaling and induction of Vitamin D Receptor Signaling and Differentiation<\/b><br \/>\nUhmann A; Niemann H; Lammering B; Henkel C; Hess I; Nitzki F; Fritsch A; Rosenberger A; Dullin C; Schraepler A; Reifenberger J; Schweyer S; Pietsch T; Strutz F; Schulz-Schaeffer W; Hahn H<br \/>\n<em>Mol Cancer Ther<\/em> 2011;10:2179-2188<\/p>\n<p><b>Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1 mutant mice<\/b><br \/>\nNitzki F; Zibat A; Frommhold A; Schneider A; Schulz-Schaeffer W; Braun T; Hahn H<br \/>\n<em>Oncogene<\/em> 2011 Oct 27;30(43):4428-36.<\/p>\n<p><b>T cell development critically depends on prethymic stromal Patched expression<\/b><br \/>\nUhmann A; van den Brandt J; Dittmann K; He\u00df I; Dressel R; Binder C; L\u00fchder F; Christiansen H; Fassnacht M; Bhandoola A; Wienands J; Reichardt HM; Hahn H<br \/>\n<em>The Journal of Immunology<\/em> 2011, 186: 3383\u20133391.<\/p>\n<p><b>Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene negative alveolar rhabdomyosarcoma<\/b><br \/>\nZibat A; Missiaglia E; Rosenberger A; Pritchard-Jones K; Shipley J; Hahn H; Fulda S<br \/>\n<em>Oncogene <\/em>2010 Dec 2;29(48):6323-30.<\/p>\n<p><b>Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of <em>Ptch<\/em> mutant mice via CaMKII<\/b><br \/>\nNitzki F; Zibat A; K\u00f6nig S; Wijgerde M; Rosenberger A; Brembeck F; Carstens PO; Frommhold A; Uhmann A; Klingler S; Reifenberger J; Pukrop T; Aberger F; Schulz-Schaeffer W; Hahn H<br \/>\n<em>Cancer Research<\/em> 2010 Apr 1;70(7):2739-48.<\/p>\n<p><b>Comment on \u201eDirect Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreERT2\u201d<\/b><br \/>\nUhmann A; Dittmann K; Wienands J; Hahn H<br \/>\n<em>The Journal of Immunology<\/em> 2009 Sep 1;183(5):2891; author reply 2891-2.<\/p>\n<p><b>Time-point and dosage of gene inactivation determine the tumor spectrum in conditional <em>Ptch<\/em> knockouts<\/b><br \/>\nZibat A; Uhmann A; Nitzki F; Wijgerde M; Frommhold A; Heller T; Armstrong V; Wojnowski L; Quintanilla-Martinez L; Reifenberger J; Schulz-Schaeffer W; Hahn H<br \/>\n<em>Carcinogenesis <\/em>2009 30(6):918-26.<\/p>\n<p><b>Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the Hedgehog pathway<\/b><br \/>\nvan Dop WA; Uhmann A; Wijgerde M; Heijmans J; Offerhaus GJ; van den Bergh Weerman MA; Hommes DW; Hardwick JC; Hahn H; van den Brink GR<br \/>\n<em>Gastroenterology <\/em>2009 136(7):2195-2203.e1-7.<\/p>\n<p><b>Antitumor effects of a combined 5-aza-2\u2019deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in <em>Ptch<\/em> mutant mice<\/b><br \/>\nEcke I; Petry F; Rosenberger A; Tauber S; M\u00f6nkemeyer S; Hess I; Dullin C; Kimmina S; Pirngruber J; Johnsen SA; Uhmann A; Nitzki F; Wojnowski L; Schulz-Schaeffer W; Witt O; Hahn H<br \/>\n<em>Cancer Research<\/em> 2009 69:887-95<\/p>\n<p><b>Cyclopamine treatment of full-blown Hh\/Ptch-associated RMS partially inhibits Hh\/Ptch signaling, but not tumor growth<\/b><br \/>\nEcke I; Rosenberger A; Obenauer S; Dullin; Aberger F; Kimmina S; Schweyer S; Hahn H<br \/>\n<em>Mol Carcinogenesis<\/em> 2008 47:361-72<\/p>\n<p><b>Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice<\/b><br \/>\nEichenmuller M; Bauer R; Von Schweinitz D; Hahn H; Kappler R<br \/>\n<em>Int J Oncol.<\/em> 2007 Aug;31(2):405-12.<\/p>\n<p><b>The Hedgehog receptor Patched controls lymphoid lineage commitment<\/b><br \/>\nUhmann A; Dittmann K; Nitzki F; Dressel R; Koleva M; Frommhold A; Zibat A; Binder C; Adham I; Nitsche M; Heller T; Armstrong V; Schulz-Schaeffer W; Wienands J; Hahn H<br \/>\n<em>Blood <\/em>2007 Sep 15;110(6):1814-23.<\/p>\n<p><b>Identification of a genetic contamination in a commercial mouse strain using two panels of polymorphic markers<\/b><br \/>\nNitzki F; Kruger A; Reifenberg K; Wojnowski L; Hahn H<br \/>\n<em>Lab Anim.<\/em> 2007 Apr;41(2):218-28.<\/p>\n<p><b>Mode of <em>PTCH1<\/em>\/<em>Ptch1<\/em>-associated tumor formation: insights from mutant <em>Ptch1<\/em> mice<\/b><br \/>\nHahn H<br \/>\nHedgehog-Gli signaling in Human disease. Editor: Ariel Ruiz I Altaba. Landes <em>Bioscience\/Eurekah<\/em>. 2006<\/p>\n<p><b>Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice<\/b><br \/>\nPazzaglia S; Tanori M; Mancuso M; Rebessi S; Leonardi S; Di Majo V; Covelli V; Atkinson MJ; Hahn H; Saran S<br \/>\n<em>Oncogene <\/em>2006, 25(8), 1165-73<\/p>\n<p><b>NAD(P)H oxidase and MRP genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity<\/b><br \/>\nWojnowski L; Kulle B; Schirmer M; Schl\u00fcter G; Schmidt A; Rosenberger A; Vonhof S; Bickeb\u00f6ller H; Toliat MR; Suk EK; Tzvetkov M; Kruger A; Seifert, S; Kloess M: Hahn H; Loeffler M; N\u00fcrnberg P; Pfreundschuh M; Tr\u00fcmper L; Brockm\u00f6ller J; Hasenfuss G<br \/>\n<em>Circulation <\/em>2005, 112(24), 3754-62<\/p>\n<p><b>A model for <em>PTCH1\/Ptch1<\/em>-associated tumors comprising mutational inactivation and gene silencing<\/b><br \/>\nUhmann A; Ferch U; Bauer R; Tauber S; Arziman Z; Chen C; Hemmerlein B; Wojnowski L; Hahn H<br \/>\n<em>Int. J. Oncology<\/em> 2005, 27(6),1567-75<\/p>\n<p><b>Pseudotrisomy 13: clinical findings and genetic implications<\/b><br \/>\nSchulz S; Gerloff C; Kalinski T; Mawrin C; Kanakis D; Haas D; Hahn H; Wieacker P<br \/>\n<em>Fetal Diagn Ther.<\/em> 2005, 20(6), 501-3<\/p>\n<p><b>The <em>Fem1a<\/em> gene is down-regulated in rhabdomyosarcoma<\/b><br \/>\nVentura-Holman T; Hahn H; Subauste JS; Maher JF<br \/>\n<em>Tumour Biol.<\/em> 2005, 26(6), 294-299<\/p>\n<p><b>Pleiotropic effects of sonic hedgehog on muscle satellite cells<\/b><br \/>\nKoleva M; Kappler R; Vogler M; Herwig A; Fulda S; Hahn H<br \/>\n<em>Cell Mol Life Sci.<\/em> 2005, 62(16), 1863-70.<\/p>\n<p><b>Functions of Sorting Nexin17 Domains and Recognition Motif for P-selectin Trafficking<\/b><br \/>\nKnauth P; Schl\u00fcter T; Czubayko M; Kirsch C; Florian V; Schreckenberger S; Hahn H; Bohnensack R.<br \/>\n<em>J Mol Biol. <\/em>2005, 347(4), 813-25<\/p>\n<p><b>Profiling the molecular difference between <em>Patched1<\/em>&#8211; and <em>p53<\/em>-dependent rhabdomyosarcoma<\/b><br \/>\nKappler R; Bauer R; Calzada-Wack J; Rosemann M; Hemmerlein B; Hahn H<br \/>\n<em>Oncogene <\/em>2004, 23(54), 8785-95<\/p>\n<p><b>Analysis of the PTCH1 signaling pathway in ovarian dermoids<\/b><br \/>\nLevanat S; Kappler R; Hemmerlein B; D\u00f6ring P; Musani V; Komar A; Oreskovic S; Pavelic B; Hahn H<br \/>\n<em>Int. J. Mol. Medicine <\/em>2004, 14(5), 793-799<\/p>\n<p><b>Genetic mapping of a major susceptibility locus to murine rhabdomyosarcoma<\/b><br \/>\nHahn H; Nitzki F; Schorban T; Hemmerlein B; Threadgill D; Rosemann M<br \/>\n<em>Genomics <\/em>2004, 84(5), 853-858<\/p>\n<p><b>Tumor associated E-cadherin mutations do not induce Wnt target gene expression, but effect E-cadherin repressors<\/b><br \/>\nLaux H; Mader MT; Smida J; BudcziesJ; Kappler K; Hahn H; Bl\u00f6chinger M; Schnitzbauer U; Eckardt-Schupp F; H\u00f6fler H; Becker KF<br \/>\n<em>Lab Invest.<\/em> 2004, 84(10), 1372-1386<\/p>\n<p><b>Transcriptional up-regulation of <em>Gadd45a<\/em> in Patched-associated medulloblastoma<\/b><br \/>\nKappler R; He\u00df I; Schlegel J; Hahn H<br \/>\n<em>Int. J. Oncology<\/em> 2004, 25(1), 113-121<\/p>\n<p><b>Modulation of Patched-associated Susceptibility to Radiation Induced Tumorigenesis by Genetic Background<\/b><br \/>\nPazzaglia S; Mancuso M; Tanori M; Atkinson MJ; Merola P; Rebessi S; Di Majo V; Covelli V; Hahn H; Saran A<br \/>\n<em>Cancer Research<\/em> 2004, 64(11), 3798-806<\/p>\n<p><b>Basal Cell Carcinoma and its Development: Insights from Radiation Induced Tumors in <em>Ptch1<\/em> Deficient Mice<\/b><br \/>\nMancuso M; Pazzaglia S; Tanori M; Hahn H; Merola P; Rebessi S; Atkinson MJ; Di Majo V; Covelli V; Saran A<br \/>\n<em>Cancer Research<\/em> 2004, 64(3), 934-41.<\/p>\n<p><b>Molecular characterisation of Patched-associated rhabdomyosarcoma<\/b><br \/>\nKappler R; Calzada-Wack J; Schnitzbauer U; Piontek G; Graedler F; Adamski J; Heinzmann U; Schlegel J; Hemmerlein B; Quintanilla-Martinez L; Hahn H<br \/>\n<em>J. of Pathology<\/em> 2003, 200(3), 348-56<\/p>\n<p><b>Gene expression analysis of murine cells producing of amphotropic mouse leukemia viruses at 32oC and 37oC cultivation temperature<\/b><br \/>\nBeer C; Buhr P; Hahn H; Laubner D; Wirth M<br \/>\n<em>J Gen Virology<\/em> 2003, 84, 1677-1686<\/p>\n<p><b>The Patched Polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk<\/b><br \/>\nChang-Claude J; Dunning A; Schnitzbauer U; Galmbacher P; Tee L; Wjst M; Chalmers J; Zemzoum I; Harbeck N; Pharoah PDP; Hahn H<br \/>\n<em>Int. J. Cancer<\/em> 2003 March 1;103(6):779-83<\/p>\n<p><b>High Incidence of Medulloblastoma Following X Ray-Irradiation of Newborn ptch Heterozygous Mice<\/b><br \/>\nPazzaglia S; Mancuso M; Atkinson M; Tanori M; Rebessi S; Di Majo V; Covelli V; Hahn H; Saran A<br \/>\n<em>Oncogene <\/em>2002 Oct 24;21(49):7580-4<\/p>\n<p><b>CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer<\/b><br \/>\nPharoah PD; Oliveira C; Machado JC; Keller G; Vogelsang H; Laux H; Becker KF; Hahn H; Paproski SM; Brown LA; Caldas C; Huntsman D<br \/>\n<em>Int. J. Cancer<\/em> 2002 Sep 10;101(2):196-197.<\/p>\n<p><b>Analysis of the PTCH coding region in human rhabdomyosarcoma<\/b><br \/>\nCalzada-Wack J; Schnitzbauer U; Walch A; Wurster KH, Kappler R; Nathrath M; Hahn H<br \/>\n<em>Hum. Mutat<\/em> 2002 Sep;20(3):233-4.<\/p>\n<p><b>Unbalanced overexpression of the mutant allele in murine Patched mutants<\/b><br \/>\nCalzada-Wack J; Kappler R; Schnitzbauer U; Richter T; Nathrath M; Rosemann M; Wagner SN; Hein R; Hahn H<br \/>\n<em>Carcinogenesis <\/em>2002; 23(5):727-734<\/p>\n<p><b>Absence of delta-9-tertahydrocannabinol dysphoric effects in dynorphin-deficient mice<\/b><br \/>\nZimmer A; Valjent E; Konig M; Zimmer AM; Robledo P; Hahn H; Valverde O; Maldonado R<br \/>\n<em>J. Neurosci<\/em> 2001; 21 (23): 9499-9505.<\/p>\n<p><b>Genetic evidence that Sil is required for the sonic hedgehog response pathway<\/b><br \/>\nIzraeli S; Lowe LA; Bertness VL; Campaner S; Hahn H; Kirsch IR; Kuehn MR<br \/>\n<em>Genesis <\/em>2001; 31(2): 72-7.<\/p>\n<p><b>Basalzelln\u00e4vussyndrom<\/b><br \/>\nMolekularmedizinische Grundlagen von heredit\u00e4ren Tumorerkrankungen, Detlev Ganten und Klaus Ruckpaul (Hrsg.) Springer-Verlag Berlin Heidelberg 2001<\/p>\n<p><b>Neurological and psychiatric manifestations in a family with a mutation in exon 2 of the GTP cyclohydrolase gene<\/b><br \/>\nHahn H; Trant MR; BrownsteinMJ; Harper RA; Milstien S; Butler IJ<br \/>\n<em>Archives of Neurology<\/em> 2001; 58 (5): 749-755<\/p>\n<p><b>Genetically determined susceptibility markers in skin cancer and their application to chemoprevention<\/b><br \/>\nHahn H<br \/>\n<em>IARC Scientific Publications<\/em> 2001, 154: 93-101<\/p>\n<p><b>Patched target IGF2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma<\/b><br \/>\nHahn H; Wojnowski L; Specht K; Kappler R; Calzada-Wack J; Potter D; Zimmer AM; M\u00fcller U; Samson E; Quintinilla-Martinez; Zimmer A<br \/>\n<em>JBC<\/em> 2000 Sept; 275 (37): 28341-4<\/p>\n<p><b>The patched signaling pathway in tumorigenesis and development: lessons from animal models<\/b><br \/>\nHahn H; Wojnowski L; Miller G; Zimmer A<br \/>\n<em>J Mol Med<\/em> 1999 Feb; 77:459-468<\/p>\n<p><b>Craf-1 protein kinase is essential for mouse developement<\/b><br \/>\nWojnowski L; Stancato LF; Zimmer AM; Hahn H; Beck TW; Larner AC; Rapp UR; Zimmer A<br \/>\n<em>Mech Dev<\/em> 1998 Aug; 76(1-2):141-9.<\/p>\n<p><b>Rhabdomyosarcomas and radiation hypersensitivity in a mouse model for Gorlin syndrome<\/b><br \/>\nHahn H; Wojnowski L; Zimmer AM; Hall J; Miller G; Zimmer A<br \/>\n<em>Nat Medicine<\/em> 1998 May; 4(5): 619-622<\/p>\n<p><b>Endothelial apoptosis in Braf-deficient mice<\/b><br \/>\nWojnowski L; Zimmer AM; Beck TW; Hahn H; Bernal R; Rapp UR; Zimmer A<br \/>\n<em>Nat Genet <\/em>1997 July 16:293-297<\/p>\n<p><b>Mutations of the human homologue of Drosophila patched in the nevoid basal cell carcinoma syndrome<\/b><br \/>\nHahn H; Wicking C; Zaphiropoulos P; Gailani M; Shanley S; Chidambaram A; Vorechovsky I; Holmberg E; Unden A; Gillies S; Negus K; Smyth I; Pressman C; Leffell D; Gerrard B; Goldstein A; Wainright B; Toftgard R; Chenevix-Trench G; Dean M; Bale A<br \/>\n<em>Cell <\/em>1996 June14; 85(6): 841-51<\/p>\n<p><b>A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities<\/b><br \/>\nHahn H; Christiansen J; Wicking C; Zaphiropoulos P; Chidambaram A; Gerrard B; Vorechovsky I; Bale A; Toftgard R; Wainwright B; Dean M<br \/>\n<em>JBC <\/em>1996 May 24; 271(21): 12125-8<\/p>\n<p><b>Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis<\/b><br \/>\nRosener M; Hahn H; Kranz M; Heeney J; Rethwilm A<br \/>\n<em>J Med Virol<\/em> 1996 Mar;48(3):222-6<\/p>\n<p><b>Markers of foamy virus infections in monkeys, apes, and accidentally infected humans: appropriate testing fails to confirm suspected foamy virus prevalence in humans<\/b><br \/>\nSchweizer M; Turek R; Hahn H; Schliephake A; Netzer KO; Eder G; Reinhardt M; Rethwilm A; Neumann-Haefelin D<br \/>\n<em>AIDS Res Hum Retroviruses <\/em>1995 Jan;11(1):161-70<\/p>\n<p><b>The Raf-1 serine\/threonine protein kinase<\/b><br \/>\nMagnuson NS; Beck T; Vahidi H; Hahn H; Smola U; Rapp UR<br \/>\n<em>Semin Cancer Biol <\/em>1994 Aug;5(4):247-53<\/p>\n<p><b>Reactivity of primate sera to foamy virus Gag and Bet proteins<\/b><br \/>\nHahn H; Baunach G; Brautigam S; Mergia A; Neumann-Haefelin D; Daniel MD; McClure MO; Rethwilm A<br \/>\n<em>J Gen Virol<\/em> 1994 Oct;75 ( Pt 10):2635-44<\/p>\n<p><b>Functional analysis of human foamy virus accessory reading frames<\/b><br \/>\nBaunach G; Maurer B; Hahn H; Kranz M; Rethwilm A<br \/>\n<em>J Virol<\/em> 1993 Sep;67(9):5411-8<\/p>\n<p><b>Genotoxicity of 1,3-dichloro-2-propanol in the SOS chromotest and in the Ames test. Elucidation of the genotoxic mechanism<\/b><br \/>\nHahn H; Eder E; Deininger C<br \/>\n<em>Chem Biol Interact<\/em> 1991;80(1):73-88<\/p>\n<p><b>Induction of SOS repair by monofunctional methansulfonates in various Escherichia coli strains. Structure-activity relationships in comparison with mutagenicity in Salmonella typhimurium<\/b><br \/>\nEder E; Favre A; Deininger C; Hahn H; K\u00fctt W<br \/>\n<em>Mutagenesis <\/em>1989;4(3):179-86.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/mk_page_section][mk_page_section][vc_column][vc_empty_space height=&#8221;100&#8243;][\/vc_column][\/mk_page_section]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row attached=&#8221;true&#8221; padding=&#8221;2&#8243;][vc_column][vc_empty_space height=&#8221;60&#8243;][mk_padding_divider size=&#8221;32&#8243;][vc_column_text align=&#8221;center&#8221;] Section of Molecular Developmental Genetics [\/vc_column_text][vc_empty_space][vc_row_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;.vc_custom_1702303005767{margin-bottom: 0px !important;}&#8221;] Dr. rer. nat. Yehan Bian PostDoc yehan.bian@med.uni-goettingen.de [\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;.vc_custom_1761224699728{margin-bottom: 0px !important;}&#8221;] PD Dr. rer. nat. Anja Uhmann Head of lab auhmann@gwdg.de anja.uhmann@med.uni-goettingen.de [\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;.vc_custom_1656422571451{margin-bottom: 0px !important;}&#8221;] Prof. Dr. med. Heidi Hahn Group leader hhahn@gwdg.de [\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=&#8221;80&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/6&#8243;][vc_icon [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7663,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8007","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Molecular Developmental Genetics - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"Our goal is to understand the role of the hedgehog and wnt signalling cascades in the formation of tumors of the skeletal muscle, skin and brain.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/research\/molecular-developmental-genetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular Developmental Genetics - 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