{"id":9184,"date":"2017-07-07T13:08:57","date_gmt":"2017-07-07T11:08:57","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/genetic-counselling\/rare-diseases\/zentrum-fuer-progeroide-erkrankungen\/"},"modified":"2025-12-11T14:58:57","modified_gmt":"2025-12-11T13:58:57","slug":"center-for-progeroid-syndromes","status":"publish","type":"page","link":"https:\/\/www.humangenetik-umg.de\/en\/genetic-counselling\/rare-diseases\/center-for-progeroid-syndromes\/","title":{"rendered":"Center for Progeroid Syndromes"},"content":{"rendered":"
[mk_page_section bg_image=”https:\/\/www.humangenetik-umg.de\/wp-content\/uploads\/2017\/05\/foto_progerie.jpg” bg_position=”center center” bg_repeat=”no-repeat” bg_stretch=”true” min_height=”500″ full_width=”true” section_id=”header-bild” sidebar=”sidebar-1″][vc_column][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_empty_space height=”50px”][vc_column_text align=”center”]\n

Center for Progeroid Syndromes<\/span>
\n<\/span><\/h1>\n[\/vc_column_text][vc_empty_space height=”15px”][vc_row_inner is_fullwidth_content=”false”][vc_column_inner][\/vc_column_inner][\/vc_row_inner][mk_padding_divider size=”80″ visibility=”hidden-sm”][mk_padding_divider visibility=”visible-sm”][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_column_text]The Center for Progeroid Syndromes is a specialized center at the Center for Rare Diseases G\u00f6ttingen (ZSEG). It unites the outstanding expertise and experience of physicians and scientists in the research, diagnostics and management of these very rare disorders and offers one-stop genetic counselling and clinical care of patients and their families.[\/vc_column_text][mk_padding_divider size=”60″][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column width=”1\/2″][\/vc_column][vc_column width=”1\/2″][vc_icon icon_fontawesome=”fa fa-file-pdf-o” color=”custom” size=”xl” custom_color=”#66cc99″ link=”url:https%3A%2F%2Fwww.humangenetik-umg.de%2Fwp-content%2Fuploads%2F2017%2F07%2Fhumangenetik_goettingen_progerien.pdf||target:%20_blank|”][vc_column_text css=”.vc_custom_1537860391760{margin-bottom: 0px !important;}”]\n

Information Leaflet Center for Progeroid Syndromes<\/span><\/a><\/h4>\n[\/vc_column_text][mk_padding_divider size=”80″][\/vc_column][\/mk_page_section][mk_page_section sidebar=”sidebar-1″][vc_column][vc_tta_accordion style=”outline” shape=”square” color=”vista-blue” c_icon=”” active_section=”1″][vc_tta_section i_icon_fontawesome=”fa fa-question” add_icon=”true” title=”What are progeroid syndromes?” tab_id=”1499412205290-d3d43933-b29d”][vc_column_text]Progeroid syndromes are rare congenital disorders characterized by signs and symptoms of premature or accelerated aging. They may, for example, lead to early manifestation of age-associated conditions such as atherosclerosis, cancer or neurodegeneration.[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=”fa fa-question” add_icon=”true” title=”What are the key features of progeroid syndromes?” tab_id=”1499412205841-d7e90ac9-3ac7″][vc_column_text]Typical features of progeroid syndromes include loss of hair, brittle bones, atherosclerosis, hearing loss, lipodystrophy. As these aging-associated features do usually not affect all organ systems or tissues, these disorders are also called \u201csegmental progeroid syndromes\u201d.[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=”fa fa-question” add_icon=”true” title=”What is the cause of progeroid syndromes?” tab_id=”1499412206354-04debc41-962d”][vc_column_text]Progeroid syndromes are mostly monogenic disorders, i.e. they are caused by a defect in a single gene. As far as the specific genes are known, they encode mainly proteins that impact on the nuclear membrane or the chromatin structure and transcription or act in various mechanisms involved in DNA damage repair.[\/vc_column_text][\/vc_tta_section][vc_tta_section i_icon_fontawesome=”fa fa-question” add_icon=”true” title=”How are progeroid syndromes diagnosed?” tab_id=”1499412206845-5520764a-1b3e”][vc_column_text]Numerous progeroid syndromes have been described with often considerably overlapping phenotypes, which makes it challenging to establish a precise clinical diagnosis. We have gained the long experience needed to evaluate and distinguish progeroid conditions, and next-generation sequencing technology provides us with tools that facilitate their molecular diagnosis. In specific panels we can now simultaneously analyze a large number of potentially progeria-causing genes.[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][vc_empty_space height=”15px”][mk_padding_divider size=”60″][\/vc_column][\/mk_page_section][mk_page_section][vc_column width=”2\/3″][vc_column_text el_class=”titlebox beratung-01 white”]\n

Research on progeroid syndromes<\/h2>\n[\/vc_column_text][vc_empty_space][vc_column_text]Progeroid syndromes are one of our key research areas. We use whole-genome and whole-exome sequencing to discover new associated genes. Then we functionally analyze identified variants and their encoded proteins to explore how they act in signaling pathways and molecular mechanisms and what cellular processes underlie aging-associated pathologies.<\/p>\n

In particular, our researchers focus on [\/vc_column_text][mk_custom_list icon_color=”#66cc99″]\n