{"id":11465,"date":"2020-05-06T14:28:54","date_gmt":"2020-05-06T12:28:54","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=11465"},"modified":"2020-05-06T14:28:54","modified_gmt":"2020-05-06T12:28:54","slug":"gene-of-the-month-april-tet2","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/","title":{"rendered":"Gene of the Month &#8211; April: TET2"},"content":{"rendered":"<p>Variants of the <em>TET2<\/em> gene might be a risk factor for the development of neurodegenerative diseases. In their study published in <em>The American Journal of Human Genetics<\/em>, US researchers initially performed whole-genome sequencing in 493 patients with Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and 671 healthy persons. Their bioinformatic analyses revealed that rare <em>TET2<\/em> variants nearly doubled a person&#8217;s risk of developing AD, ALS or FTD. When they compared their results with previously existing genetic data from other cohorts of patients with neurodegenerative disorders, they also found <em>TET2<\/em> variants associating with the diseases. Intriguingly, the relevant variants were both in the coding and non-coding, regulatory parts of TET2.<\/p>\n<p><em>TET2<\/em> encodes the ten-eleven translocation 2 protein, a member of the TET family of proteins, which are involved in the removal of DNA methylation. DNA methylation is an epigenetic mechanism of gene expression regulation and also plays a role in aging. TET2 is known to catalyze hydroxymethylation of cytosine residues and is highly expressed in the brain. The authors of the study therefore assume that variants affecting TET2 function impact on the aging process of the brain and contribute to the development of neurodegenerative disorders.<\/p>\n[vc_column_text] Cochran JN, Geier EG, Bonham LW, \u2026 Alzheimer\u2019s Disease Neuroimaging Initiative. Non-Coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases. <em>Am J Hum Genet.<\/em> 2020 Apr 21; doi: 10.1016\/j.ajhg.2020.03.010 [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/doi.org\/10.1016\/j.ajhg.2020.03.010&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>Variants of the TET2 gene might be a risk factor for the development of neurodegenerative diseases. In their study published in The American Journal of Human Genetics, US researchers initially performed whole-genome sequencing in 493 patients with Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and 671 healthy persons. Their bioinformatic analyses [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-11465","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month - April: TET2 - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"Variants of the TET2 gene might be a risk factor for the development of neurodegenerative diseases according to a US study..\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month - April: TET2 - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"Variants of the TET2 gene might be a risk factor for the development of neurodegenerative diseases according to a US study..\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-06T12:28:54+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/2273960540ea0d585310d12c8277e5cb\"},\"headline\":\"Gene of the Month &#8211; April: TET2\",\"datePublished\":\"2020-05-06T12:28:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/\"},\"wordCount\":277,\"commentCount\":0,\"articleSection\":[\"Gene of the Month\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/\",\"name\":\"Gene of the Month - April: TET2 - Institut f\u00fcr Humangenetik\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\"},\"datePublished\":\"2020-05-06T12:28:54+00:00\",\"author\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/2273960540ea0d585310d12c8277e5cb\"},\"description\":\"Variants of the TET2 gene might be a risk factor for the development of neurodegenerative diseases according to a US study..\",\"breadcrumb\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.humangenetik-umg.de\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gene of the Month &#8211; April: TET2\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/\",\"name\":\"Institut f\u00fcr Humangenetik\",\"description\":\"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/2273960540ea0d585310d12c8277e5cb\",\"name\":\"KB\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"caption\":\"KB\"},\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gene of the Month - April: TET2 - Institut f\u00fcr Humangenetik","description":"Variants of the TET2 gene might be a risk factor for the development of neurodegenerative diseases according to a US study..","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/","og_locale":"en_US","og_type":"article","og_title":"Gene of the Month - April: TET2 - Institut f\u00fcr Humangenetik","og_description":"Variants of the TET2 gene might be a risk factor for the development of neurodegenerative diseases according to a US study..","og_url":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/","og_site_name":"Institut f\u00fcr Humangenetik","article_published_time":"2020-05-06T12:28:54+00:00","author":"KB","twitter_card":"summary_large_image","twitter_misc":{"Written by":"KB","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/#article","isPartOf":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/"},"author":{"name":"KB","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/2273960540ea0d585310d12c8277e5cb"},"headline":"Gene of the Month &#8211; April: TET2","datePublished":"2020-05-06T12:28:54+00:00","mainEntityOfPage":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/"},"wordCount":277,"commentCount":0,"articleSection":["Gene of the Month"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/","url":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/","name":"Gene of the Month - April: TET2 - Institut f\u00fcr Humangenetik","isPartOf":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/#website"},"datePublished":"2020-05-06T12:28:54+00:00","author":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/2273960540ea0d585310d12c8277e5cb"},"description":"Variants of the TET2 gene might be a risk factor for the development of neurodegenerative diseases according to a US study..","breadcrumb":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-tet2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.humangenetik-umg.de\/en\/"},{"@type":"ListItem","position":2,"name":"Gene of the Month &#8211; April: TET2"}]},{"@type":"WebSite","@id":"https:\/\/www.humangenetik-umg.de\/en\/#website","url":"https:\/\/www.humangenetik-umg.de\/en\/","name":"Institut f\u00fcr Humangenetik","description":"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/2273960540ea0d585310d12c8277e5cb","name":"KB","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g","caption":"KB"},"url":"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/"}]}},"_links":{"self":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts\/11465","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/comments?post=11465"}],"version-history":[{"count":0,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts\/11465\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/media?parent=11465"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/categories?post=11465"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/tags?post=11465"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}