{"id":11550,"date":"2020-07-07T11:01:55","date_gmt":"2020-07-07T09:01:55","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=11550"},"modified":"2020-07-07T11:01:55","modified_gmt":"2020-07-07T09:01:55","slug":"gene-of-the-month-june-gp2","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/","title":{"rendered":"Gene of the Month &#8211; June: GP2"},"content":{"rendered":"<p><em>GP2<\/em> gene variants may be associated with an increased risk for pancreatic cancer. This is suggested by the results of a meta-analysis of three genome-wide association studies published in <em>Nature Communications<\/em>. Scientists from Japan included the genome data of more than 2,000 pancreatic cancer patients and more than 32,000 healthy control individuals of East Asian ancestry in their analysis to discover novel susceptibility loci for pancreatic cancer. They found three loci of genome-wide significance. The lead single-nucleotide polymorphism (SNP) is a non-synonymous variant in the <em>GP2<\/em> gene, which codes for the pancreatic zymogen granule membrane protein. GP2 is a membrane protein that is secreted from the zymogen granules of the pancreas, but its precise function is largely unknown. In their functional experiments, the researchers showed that the identified GP2 variant has an impact on KRAS activity. Interestingly, mutations in the <em>KRAS<\/em> gene are among the most common genetic variants found in pancreatic cancer.<\/p>\n[vc_column_text] Lin Y, Nakatochi M, Hosono Y, et al. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. <em>Nat Commun.<\/em> 2020;11(1):3175. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32581250&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>GP2 gene variants may be associated with an increased risk for pancreatic cancer. This is suggested by the results of a meta-analysis of three genome-wide association studies published in Nature Communications. Scientists from Japan included the genome data of more than 2,000 pancreatic cancer patients and more than 32,000 healthy control individuals of East Asian [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-11550","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month - June: GP2 - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month - June: GP2 - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"GP2 gene variants may be associated with an increased risk for pancreatic cancer. This is suggested by the results of a meta-analysis of three genome-wide association studies published in Nature Communications. Scientists from Japan included the genome data of more than 2,000 pancreatic cancer patients and more than 32,000 healthy control individuals of East Asian [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2020-07-07T09:01:55+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"headline\":\"Gene of the Month &#8211; June: GP2\",\"datePublished\":\"2020-07-07T09:01:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/\"},\"wordCount\":225,\"commentCount\":0,\"articleSection\":[\"Gene of the Month\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/\",\"name\":\"Gene of the Month - June: GP2 - Institut f\u00fcr Humangenetik\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\"},\"datePublished\":\"2020-07-07T09:01:55+00:00\",\"author\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.humangenetik-umg.de\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gene of the Month &#8211; June: GP2\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/\",\"name\":\"Institut f\u00fcr Humangenetik\",\"description\":\"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\",\"name\":\"KB\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"caption\":\"KB\"},\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gene of the Month - June: GP2 - Institut f\u00fcr Humangenetik","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/","og_locale":"en_US","og_type":"article","og_title":"Gene of the Month - June: GP2 - Institut f\u00fcr Humangenetik","og_description":"GP2 gene variants may be associated with an increased risk for pancreatic cancer. This is suggested by the results of a meta-analysis of three genome-wide association studies published in Nature Communications. Scientists from Japan included the genome data of more than 2,000 pancreatic cancer patients and more than 32,000 healthy control individuals of East Asian [&hellip;]","og_url":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/","og_site_name":"Institut f\u00fcr Humangenetik","article_published_time":"2020-07-07T09:01:55+00:00","author":"KB","twitter_card":"summary_large_image","twitter_misc":{"Written by":"KB","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/#article","isPartOf":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/"},"author":{"name":"KB","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675"},"headline":"Gene of the Month &#8211; June: GP2","datePublished":"2020-07-07T09:01:55+00:00","mainEntityOfPage":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/"},"wordCount":225,"commentCount":0,"articleSection":["Gene of the Month"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/","url":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/","name":"Gene of the Month - June: GP2 - Institut f\u00fcr Humangenetik","isPartOf":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/#website"},"datePublished":"2020-07-07T09:01:55+00:00","author":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675"},"breadcrumb":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-gp2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.humangenetik-umg.de\/en\/"},{"@type":"ListItem","position":2,"name":"Gene of the Month &#8211; June: GP2"}]},{"@type":"WebSite","@id":"https:\/\/www.humangenetik-umg.de\/en\/#website","url":"https:\/\/www.humangenetik-umg.de\/en\/","name":"Institut f\u00fcr Humangenetik","description":"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675","name":"KB","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g","caption":"KB"},"url":"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/"}]}},"_links":{"self":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts\/11550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/comments?post=11550"}],"version-history":[{"count":0,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts\/11550\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/media?parent=11550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/categories?post=11550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/tags?post=11550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}