{"id":12255,"date":"2021-12-02T11:17:35","date_gmt":"2021-12-02T10:17:35","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=12255"},"modified":"2021-12-02T11:17:35","modified_gmt":"2021-12-02T10:17:35","slug":"gene-of-the-month-november-lztfl1","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-lztfl1\/","title":{"rendered":"Gene of the Month &#8211; November: LZTFL1"},"content":{"rendered":"<p>A gene variant in <em>LZTFL1<\/em> is probably responsible for a twofold increased risk of dying of COVID-19. This has been found by British scientists at the University of Oxford. Using a machine learning approach, they analyzed data from several large genome-wide association studies which had previously revealed an associated stretch of DNA on chromosome 3. Now the scientists uncovered <em>LZTFL1<\/em> as a candidate gene for increasing the risk of respiratory failure from COVID-19. Further molecular genetic analyses and investigations in cell models provided insights into the gene&#8217;s function.<\/p>\n<p>The identified variant affects a so called enhancer, a DNA region that acts like a switch regulating how genes are expressed, and thereby increases the function of the <em>leucine zipper transcription factor-like 1<\/em> protein. LZTFL1 has not been very well studied so far, but the results of the recent study show that it is produced in epithelial cells of the respiratory tract and is associated with lung function. The researchers found that the high-risk variant, which is present in 15 % of people of European ancestry and in more than 60 % of people with South Asian ancestry, causes increased inhibition of the cells&#8217; proper response to infection. With these results, published in <em>Nature Genetics<\/em>, the study raises the possibility that LZTFL1 could be a potential target for the treatment of COVID-19.<\/p>\n[vc_column_text] Downes DJ, Cross AR, Hua P, \u2026 Hughes JR. Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus. <em>Nat Genet<\/em>. 2021 Nov;53(11):1606-1615. doi: 10.1038\/s41588-021-00955-3. Epub 2021 Nov 4. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34737427&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>A gene variant in LZTFL1 is probably responsible for a twofold increased risk of dying of COVID-19. This has been found by British scientists at the University of Oxford. Using a machine learning approach, they analyzed data from several large genome-wide association studies which had previously revealed an associated stretch of DNA on chromosome 3. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-12255","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month - November: LZTFL1 - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"A British study found a gene variant in LZTFL1 to be probably responsible for a twofold increased risk of dying of COVID-19.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-lztfl1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month - November: LZTFL1 - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"A British study found a gene variant in LZTFL1 to be probably responsible for a twofold increased risk of dying of COVID-19.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-lztfl1\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2021-12-02T10:17:35+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-lztfl1\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-lztfl1\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"headline\":\"Gene of the Month &#8211; 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