{"id":12417,"date":"2022-04-04T15:41:55","date_gmt":"2022-04-04T13:41:55","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=12417"},"modified":"2022-04-04T15:41:55","modified_gmt":"2022-04-04T13:41:55","slug":"gene-of-the-month-march-tmem106b","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-march-tmem106b\/","title":{"rendered":"Gene of the Month &#8211; March: TMEM106B"},"content":{"rendered":"<p>A study published in <em>Cell<\/em> suggests that abnormal aggregation of the protein encoded by the <em>TMEM106B <\/em>gene might be a shared feature in the development of diverse neurodegenerative diseases. Researchers from the U.S., Canada and Belgium investigated post mortem human brain tissue from patients with different proteinopathies including frontotemporal lobar degeneration and progressive supranuclear palsy. Using cyroelectron microscopy and mass spectrometry, they found and analyzed fibrous aggregations of TMEM106B in these tissue samples.<\/p>\n<p>Many degenerative diseases are caused by misfolded proteins which aggregate and form fibrous, insoluble structures called amyloid fibrils. This leads to the functional and structural damage and progressive loss of neurons. In this process, characteristic proteins as for example the tau protein, TDP43 or alpha-synuclein, are involved in the development of distinct neurodegenerative diseases. TMEM106B is a membrane protein and active in the transport of lysosomes and thus in the breakdown and removal of excess or old cell parts. The results of the current study indicate that fibrillization of TMEM106B might be an unknown shared mechanism underlying neurodegeneration. Further evidence of this new mechanism is provided by two other studies published at the same time in <em>Nature<\/em>.<\/p>\n[vc_column_text] Chang A, Xiang X, Wang J, \u2026 Fitzpatrick AWP. Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases. <em>Cell<\/em>. 2022 Mar 1:S0092-8674(22)00259-8. doi: 10.1016\/j.cell.2022.02.026. Epub ahead of print. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35247328&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n<p>Jiang YX, Cao Q, Sawaya MR, \u2026 Eisenberg DS. Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43. <em>Nature<\/em>. 2022 Mar 28. doi: 10.1038\/s41586-022-04670-9.<\/p>\n<p>Schweighauser M, Arseni D, Bacioglu M, \u2026 Scheres SHW. Age-dependent formation of TMEM106B amyloid filaments in human brains. <em>Nature<\/em>. 2022 Mar 28. doi: 10.1038\/s41586-022-04650-z.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A study published in Cell suggests that abnormal aggregation of the protein encoded by the TMEM106B gene might be a shared feature in the development of diverse neurodegenerative diseases. Researchers from the U.S., Canada and Belgium investigated post mortem human brain tissue from patients with different proteinopathies including frontotemporal lobar degeneration and progressive supranuclear palsy. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-12417","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month - March: TMEM106B - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"abnormal aggregation of the protein encoded by the TMEM106B gene might be a shared feature in the development of diverse neurodegenerative diseases\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-march-tmem106b\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month - March: TMEM106B - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"abnormal aggregation of the protein encoded by the TMEM106B gene might be a shared feature in the development of diverse neurodegenerative diseases\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-march-tmem106b\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-04T13:41:55+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-march-tmem106b\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-march-tmem106b\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/2273960540ea0d585310d12c8277e5cb\"},\"headline\":\"Gene of the Month &#8211; 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