{"id":12472,"date":"2022-05-03T11:26:47","date_gmt":"2022-05-03T09:26:47","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=12472"},"modified":"2022-05-03T11:26:47","modified_gmt":"2022-05-03T09:26:47","slug":"gene-of-the-month-april-acd-tpp1","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-acd-tpp1\/","title":{"rendered":"Gene of the Month &#8211; April: ACD (TPP1)"},"content":{"rendered":"<p>New insights into how the telomere shelterin protein TPP1, encoded by the <em>ACD <\/em>gene, interacts with telomerase have recently been published in <em>Nature<\/em>. In their study, researchers at the University of California, Los Angeles, have further elucidated the mechanism of telomerase activity. The telomerase enzyme complex has an essential role in cellular aging and cancer progression.<\/p>\n<p>TPP1 is one of six proteins forming the shelterin complex. Shelterin functions to shield telomeres, the chromosome ends, from damage and deterioration, and TPP1 is of critical importance in recruiting and regulating telomerase. The telomerase complex acts in specific cells by adding telomeric sequence repeats, thus counteracting the shortening of telomeres happening with each round of cell division. The researchers used the method of cryo-electron microscopy, allowing them to investigate at a particularly high resolution the structured interface which the subunits of the telomerase catalytic core, TERT and TER, form with TPP1. The new knowledge about the structural basis of telomerase activity also helps to better understand known disease-associated mutations in telomerase components and might provide a basis for the development of future drugs.<\/p>\n[vc_column_text] Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J. Structure of active human telomerase with telomere shelterin protein TPP1. <em>Nature<\/em>. 2022 Apr;604(7906):578-583. doi: 10.1038\/s41586-022-04582-8. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/35418675&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>New insights into how the telomere shelterin protein TPP1, encoded by the ACD gene, interacts with telomerase have recently been published in Nature. In their study, researchers at the University of California, Los Angeles, have further elucidated the mechanism of telomerase activity. The telomerase enzyme complex has an essential role in cellular aging and cancer [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-12472","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month - April: ACD (TPP1) - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"New insights into how the telomere shelterin protein TPP1, encoded by the ACD gene, interacts with telomerase have recently been published in Nature.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-acd-tpp1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month - April: ACD (TPP1) - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"New insights into how the telomere shelterin protein TPP1, encoded by the ACD gene, interacts with telomerase have recently been published in Nature.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-acd-tpp1\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2022-05-03T09:26:47+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-acd-tpp1\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-acd-tpp1\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"headline\":\"Gene of the Month &#8211; 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