{"id":13718,"date":"2024-09-04T11:37:52","date_gmt":"2024-09-04T09:37:52","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=13718"},"modified":"2024-09-04T11:37:52","modified_gmt":"2024-09-04T09:37:52","slug":"gene-of-the-month-august-damt-1","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/","title":{"rendered":"Gene of the Month \u2013 August: DAMT-1"},"content":{"rendered":"<p>DNA methyltransferase DAMT-1 catalyzes in <em>C. elegans<\/em> a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA (mtDNA). Impaired regulation of this modification facilitates propagation of mutant mtDNA, impairs mitochondrial function, and contributes to organismal aging. This is reported by a study published in <em>Cell Metabolism<\/em>.<\/p>\n<p>Mitochondria are responsible for generating chemical energy in the cell and possess their own DNA. The mitochondrial genome is present in multiple copies in the mitochondria and includes genes that, among others, encode proteins forming part of respiration chain complexes. How exactly mitochondrial gene expression and the number of mtDNA copies are controlled has not yet been fully elucidated.<\/p>\n<p>The authors of the study investigated the role of mtDNA 6mA in the model organism of the nematode worm <em>C. elegans<\/em>. They showed that DAMT-1 and ALKB-1, a demethylase, are localized in mitochondria and crucial for the presence of 6mA methylation on mtDNA. In their experiments, targeted modulation of the two enzymes\u2019 activities resulted in changes in the number of mtDNA copies and transcript levels, reduced oxidative phosphorylation, increased oxidative stress and a shortened lifespan.<\/p>\n[vc_column_text] Hahn A, Hung GCC, Ahier A, Dai CY, Kirmes I, Forde BM, Campbell D, Lee RSY, Sucic J, Onraet T, Zuryn S. Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans. Cell Metab. 2024 Aug 16:S1550-4131(24)00291-2. doi: 10.1016\/j.cmet.2024.07.020. Epub ahead of print. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39173633&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>DNA methyltransferase DAMT-1 catalyzes in C. elegans a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA (mtDNA). Impaired regulation of this modification facilitates propagation of mutant mtDNA, impairs mitochondrial function, and contributes to organismal aging. This is reported by a study published in Cell Metabolism. Mitochondria are responsible for generating chemical energy [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-13718","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month \u2013 August: DAMT-1 - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"DNA methyltransferase DAMT-1 catalyzes in C. elegans a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month \u2013 August: DAMT-1 - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"DNA methyltransferase DAMT-1 catalyzes in C. elegans a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2024-09-04T09:37:52+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"headline\":\"Gene of the Month \u2013 August: DAMT-1\",\"datePublished\":\"2024-09-04T09:37:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/\"},\"wordCount\":286,\"articleSection\":[\"Gene of the Month\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/\",\"name\":\"Gene of the Month \u2013 August: DAMT-1 - Institut f\u00fcr Humangenetik\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\"},\"datePublished\":\"2024-09-04T09:37:52+00:00\",\"author\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"description\":\"DNA methyltransferase DAMT-1 catalyzes in C. elegans a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA\",\"breadcrumb\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.humangenetik-umg.de\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gene of the Month \u2013 August: DAMT-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/\",\"name\":\"Institut f\u00fcr Humangenetik\",\"description\":\"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\",\"name\":\"KB\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"caption\":\"KB\"},\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gene of the Month \u2013 August: DAMT-1 - Institut f\u00fcr Humangenetik","description":"DNA methyltransferase DAMT-1 catalyzes in C. elegans a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/","og_locale":"en_US","og_type":"article","og_title":"Gene of the Month \u2013 August: DAMT-1 - Institut f\u00fcr Humangenetik","og_description":"DNA methyltransferase DAMT-1 catalyzes in C. elegans a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA","og_url":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/","og_site_name":"Institut f\u00fcr Humangenetik","article_published_time":"2024-09-04T09:37:52+00:00","author":"KB","twitter_card":"summary_large_image","twitter_misc":{"Written by":"KB","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/#article","isPartOf":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/"},"author":{"name":"KB","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675"},"headline":"Gene of the Month \u2013 August: DAMT-1","datePublished":"2024-09-04T09:37:52+00:00","mainEntityOfPage":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/"},"wordCount":286,"articleSection":["Gene of the Month"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/","url":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/","name":"Gene of the Month \u2013 August: DAMT-1 - Institut f\u00fcr Humangenetik","isPartOf":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/#website"},"datePublished":"2024-09-04T09:37:52+00:00","author":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675"},"description":"DNA methyltransferase DAMT-1 catalyzes in C. elegans a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA","breadcrumb":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-august-damt-1\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.humangenetik-umg.de\/en\/"},{"@type":"ListItem","position":2,"name":"Gene of the Month \u2013 August: DAMT-1"}]},{"@type":"WebSite","@id":"https:\/\/www.humangenetik-umg.de\/en\/#website","url":"https:\/\/www.humangenetik-umg.de\/en\/","name":"Institut f\u00fcr Humangenetik","description":"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675","name":"KB","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g","caption":"KB"},"url":"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/"}]}},"_links":{"self":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts\/13718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/comments?post=13718"}],"version-history":[{"count":0,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts\/13718\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/media?parent=13718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/categories?post=13718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/tags?post=13718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}