{"id":13949,"date":"2024-12-03T16:03:56","date_gmt":"2024-12-03T15:03:56","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=13949"},"modified":"2024-12-03T16:03:56","modified_gmt":"2024-12-03T15:03:56","slug":"gene-of-the-month-november-pnuts","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-pnuts\/","title":{"rendered":"Gene of the Month &#8211; November: PNUTS"},"content":{"rendered":"<p>A central, previously unknown role of the PNUTS complex in gene transcription depending on RNA polymerase II has been uncovered. According to a study published in <em>Molecular Cell<\/em>, the PNUTS complex controls transcriptional pause release and resumption of elongation via a mechanism that is essential for controlling gene expression. PNUTS (protein phosphatase 1 nuclear targeting subunit) is an enzyme encoded by the gene <em>PPP1R10<\/em> (<em>PNUTS<\/em>) and regulates the activity of protein phosphatase 1 (PP1). Until now, it was only known that the complex consisting of PNUTS, PP1 and other proteins is essential for transcription termination.<\/p>\n<p>The highly regulated process of gene transcription roughly takes place in three major phases: initiation, elongation and termination. During elongation, RNA polymerase II (RNAP II) moves along the DNA and copies it into a complementary mRNA strand, serving as a template for the production of proteins. However, this copying process repeatedly comes to a standstill, with RNAP II pausing. By mouse experiments and using imaging, biochemical and quantitative genomic and proteomic methods, the researchers have now discovered that the PNUTS complex is responsible for RNAP II pause release. To do this, PNUTS interacts with PP1. The study showed that PNUTS recognizes factors required for promoting pause release and elongation and enables their dephosphorylation by PP1.<\/p>\n[vc_column_text]Kelley JR, Dimitrova E, Maciuszek M, \u2026, Klose RJ. The PNUTS phosphatase complex controls transcription pause release. <em>Mol Cell.<\/em> 2024 Nov 21:S1097-2765(24)00886-4. doi: 10.1016\/j.molcel.2024.10.045. Epub ahead of print. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39603239&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>A central, previously unknown role of the PNUTS complex in gene transcription depending on RNA polymerase II has been uncovered. According to a study published in Molecular Cell, the PNUTS complex controls transcriptional pause release and resumption of elongation via a mechanism that is essential for controlling gene expression. PNUTS (protein phosphatase 1 nuclear targeting [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-13949","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month - November: PNUTS - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"A central, previously unknown role of the PNUTS complex in gene transcription depending on RNA polymerase II has been uncovered.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-pnuts\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month - November: PNUTS - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"A central, previously unknown role of the PNUTS complex in gene transcription depending on RNA polymerase II has been uncovered.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-pnuts\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-03T15:03:56+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-pnuts\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-november-pnuts\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"headline\":\"Gene of the Month &#8211; 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