{"id":14021,"date":"2025-01-06T13:04:22","date_gmt":"2025-01-06T12:04:22","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=14021"},"modified":"2025-01-06T13:04:22","modified_gmt":"2025-01-06T12:04:22","slug":"gene-of-the-month-december-il-23r","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/","title":{"rendered":"Gene of the Month \u2013 December: IL-23R"},"content":{"rendered":"<p>Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions. The authors of a study published in <em>Nature Aging<\/em> aimed at finding plasma proteins and tissue transcripts that change with age and are responsive to treatment with substances specifically designed to attack senescent cells.<\/p>\n<p>Senescent cells accumulate with age. Senescence is a type of cellular stress response in which specific signaling pathways induce a stable cell cycle arrest. Senescent cells no longer divide, but they remain metabolically active and, by secreting deleterious molecules, they impact surrounding cells. In this way, they contribute to aging-related dysfunction across multiple organs.<\/p>\n<p>IL-23R is a protein that alerts immune cells to help them fighting infections through inflammation. Overly active IL-23R, however, can result in tissue damage. The researchers found that IL-23R levels in blood of mice and humans increase with age. In preclinical studies, these IL-23R levels dropped under senolytic treatment. For the authors of the study, IL-23R is a link between cellular senescence and systemic changes in the body and acts as a mediator of interorgan communication related to aging.<\/p>\n[vc_column_text]Carver CM, Rodriguez SL, Atkinson EJ, \u2026, Schafer MJ. IL-23R is a senescence-linked circulating and tissue biomarker of aging. <em>Nat Aging<\/em>. 2024 Dec 10. doi: 10.1038\/s43587-024-00752-7. Epub ahead of print.[\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39658621&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions. The authors of a study published in Nature Aging aimed at finding plasma proteins and tissue transcripts that change with age and are responsive to treatment with substances specifically designed to attack senescent [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-14021","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month \u2013 December: IL-23R - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month \u2013 December: IL-23R - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-06T12:04:22+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"headline\":\"Gene of the Month \u2013 December: IL-23R\",\"datePublished\":\"2025-01-06T12:04:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/\"},\"wordCount\":279,\"articleSection\":[\"Gene of the Month\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/\",\"name\":\"Gene of the Month \u2013 December: IL-23R - Institut f\u00fcr Humangenetik\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\"},\"datePublished\":\"2025-01-06T12:04:22+00:00\",\"author\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"description\":\"Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.humangenetik-umg.de\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gene of the Month \u2013 December: IL-23R\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/\",\"name\":\"Institut f\u00fcr Humangenetik\",\"description\":\"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\",\"name\":\"KB\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"caption\":\"KB\"},\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gene of the Month \u2013 December: IL-23R - Institut f\u00fcr Humangenetik","description":"Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/","og_locale":"en_US","og_type":"article","og_title":"Gene of the Month \u2013 December: IL-23R - Institut f\u00fcr Humangenetik","og_description":"Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions.","og_url":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/","og_site_name":"Institut f\u00fcr Humangenetik","article_published_time":"2025-01-06T12:04:22+00:00","author":"KB","twitter_card":"summary_large_image","twitter_misc":{"Written by":"KB","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/#article","isPartOf":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/"},"author":{"name":"KB","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675"},"headline":"Gene of the Month \u2013 December: IL-23R","datePublished":"2025-01-06T12:04:22+00:00","mainEntityOfPage":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/"},"wordCount":279,"articleSection":["Gene of the Month"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/","url":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/","name":"Gene of the Month \u2013 December: IL-23R - Institut f\u00fcr Humangenetik","isPartOf":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/#website"},"datePublished":"2025-01-06T12:04:22+00:00","author":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675"},"description":"Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions.","breadcrumb":{"@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-december-il-23r\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.humangenetik-umg.de\/en\/"},{"@type":"ListItem","position":2,"name":"Gene of the Month \u2013 December: IL-23R"}]},{"@type":"WebSite","@id":"https:\/\/www.humangenetik-umg.de\/en\/#website","url":"https:\/\/www.humangenetik-umg.de\/en\/","name":"Institut f\u00fcr Humangenetik","description":"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675","name":"KB","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g","caption":"KB"},"url":"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/"}]}},"_links":{"self":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts\/14021","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/comments?post=14021"}],"version-history":[{"count":0,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/posts\/14021\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/media?parent=14021"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/categories?post=14021"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.humangenetik-umg.de\/en\/wp-json\/wp\/v2\/tags?post=14021"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}