{"id":14361,"date":"2025-05-02T10:44:50","date_gmt":"2025-05-02T08:44:50","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=14361"},"modified":"2025-05-02T10:44:50","modified_gmt":"2025-05-02T08:44:50","slug":"gene-of-the-month-april-slc7a11","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-slc7a11\/","title":{"rendered":"Gene of the Month \u2013 April: SLC7A11"},"content":{"rendered":"<p>SLC7A11 enables a slow proton efflux from lysosomes and thus plays a vital role in maintaining the acidic environment inside these cellular organelles. This has been demonstrated by a new study published in <em>Cell<\/em>. Additionally, the authors have shown that SLC7A11 malfunction can lead to the aggregation of \u03b1-synuclein, a protein linked to the development of Parkinson\u2019s disease.<\/p>\n<p>Lysosomes are spherical vesicles within the cell that use digestive enzymes to break down large molecules, allowing essential components to be recycled and waste products to be removed from the cell. To function properly, lysosomes need to maintain an acidic pH inside. This is achieved by continuously pumping hydrogen ions into the lysosome, but some protons also need to be transported out to maintain balance. While TMEM175 channels are known to mediate a fast proton efflux, it was suspected that also a second, slower pathway existed that had not yet been revealed.<\/p>\n<p>In the new study, researchers conducted extensive experiments using various knockout and knock-in cell lines, including fibroblasts from a Parkinson\u2019s patient,-and a mouse model. They found that SLC7A11 transports the amino acids cystine and glutamate across the lysosomal membrane, and in doing so, indirectly carries protons out of the lysosome. If SLC7A11 is absent or inhibited, the lysosome becomes overly acidic. As a result, degradation processes are impaired, waste materials accumulate, and a specific form of cell death known as ferroptosis can be triggered.<\/p>\n[vc_column_text]Zhou N, Chen J, Hu M, \u2026 Xu H. SLC7A11 is an unconventional H+ transporter in lysosomes. <em>Cell<\/em>. 2025 Apr 24:S0092-8674(25)00406-4. doi: 10.1016\/j.cell.2025.04.004. Epub ahead of print. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/40280132&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>SLC7A11 enables a slow proton efflux from lysosomes and thus plays a vital role in maintaining the acidic environment inside these cellular organelles. This has been demonstrated by a new study published in Cell. Additionally, the authors have shown that SLC7A11 malfunction can lead to the aggregation of \u03b1-synuclein, a protein linked to the development [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-14361","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month \u2013 April: SLC7A11 - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"SLC7A11 enables a slow proton efflux from lysosomes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-april-slc7a11\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month \u2013 April: SLC7A11 - 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