{"id":14539,"date":"2025-08-04T14:16:13","date_gmt":"2025-08-04T12:16:13","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=14539"},"modified":"2025-08-04T14:16:13","modified_gmt":"2025-08-04T12:16:13","slug":"gene-of-the-month-july-apoe","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-july-apoe\/","title":{"rendered":"Gene of the Month \u2013 July: APOE"},"content":{"rendered":"<p><em>APOE<\/em> is not only a well-known risk gene for Alzheimer\u2019s disease, but primarily an important regulator of the immune system\u2014according to a study published in <em>Nature Medicine<\/em>. Apolipoprotein E (ApoE) plays a central role in the body\u2019s lipid metabolism and is essential for transporting fatty acids, cholesterol, and other lipids to nerve cells. It has been known that a specific variant, <em>APOE4<\/em>, is the strongest genetic risk factor for late-onset Alzheimer\u2019s disease. Now, researchers have discovered that <em>APOE4<\/em> may also cause an increased vulnerability to other neurodegenerative diseases, such as frontotemporal dementia, Parkinson\u2019s disease, or amyotrophic lateral sclerosis (ALS).<\/p>\n<p>In the large-scale study, the authors used machine learning to analyze more than 10,000 blood, brain, and cerebrospinal fluid samples from individuals both with and without neurodegenerative diseases. They found that people carrying the <em>APOE4<\/em> variant share a consistent pattern of proteins, primarily related to the immune system and inflammatory processes. This protein signature was present in all samples, regardless of the disease diagnosed or whether the individual showed symptoms.<\/p>\n<p>However, the scientists also observed that while <em>APOE4<\/em> increases the biological vulnerability to a neurodegenerative disease, other factors\u2014such as high blood pressure or smoking\u2014can interact with this genetic susceptibility, depending on the specific disease. These results could form the basis for the development of precise biomarkers and tailored prevention strategies against various neurodegenerative diseases.<\/p>\n[vc_column_text]Shvetcov A, Thomson S, Cho AN, \u2026 Finney CA. Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype. <em>Aging Cell.<\/em> 2025 Apr;24(4):e14439. doi: 10.1111\/acel.14439. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/39722190&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>APOE is not only a well-known risk gene for Alzheimer\u2019s disease, but primarily an important regulator of the immune system\u2014according to a study published in Nature Medicine. Apolipoprotein E (ApoE) plays a central role in the body\u2019s lipid metabolism and is essential for transporting fatty acids, cholesterol, and other lipids to nerve cells. It has [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-14539","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month \u2013 July: APOE - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"description\" content=\"APOE is not only a well-known risk gene for Alzheimer\u2019s disease, but primarily an important regulator of the immune system\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-july-apoe\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month \u2013 July: APOE - 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