{"id":9697,"date":"2018-04-03T14:56:32","date_gmt":"2018-04-03T12:56:32","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=9697"},"modified":"2018-04-03T14:56:32","modified_gmt":"2018-04-03T12:56:32","slug":"gene-of-the-month-march-edc4","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-march-edc4\/","title":{"rendered":"Gene of the Month &#8211; March: EDC4"},"content":{"rendered":"<p>An important role of the <em>EDC4<\/em> gene in the intricate network regulating the repair of DNA damage and in cancer development has now been uncovered. In a study recently published in <em>Nature Communications<\/em>, international researchers have elucidated this previously unknown additional function of EDC4 (enhancer of mRNA decapping 4), an RNA degradation enzyme that is involved in removing the protective caps of mRNA in the p-bodies of the cytoplasm. They showed that EDC4 acts in a protein complex with BRCA1, BRIP1 and TOPBP1 in the homologous recombination pathway to repair DNA double strand breaks.<\/p>\n<p>Germline mutations of <em>BRCA1<\/em> confer an increased risk of breast and ovarian cancer, and <em>BRCA1<\/em>-mutated tumors are sensitive to treatment with PARP inhibitors. In genetic and functional analyses, the researchers have now identified dominant <em>EDC4<\/em> mutations in <em>BRCA1\/2<\/em> mutation-negative families and patients with familial breast cancer and they demonstrated that the EDC4 deficiency caused by these mutations leads to genomic instability and increased sensitivity to PARP inhibitors. These findings may thus provide the basis for further research on EDC4 as a tumor suppressor and its potential use as a molecular target in the treatment of cancer.<\/p>\n[vc_column_text] Hern\u00e1ndez G, Ram\u00edrez MJ, Minguill\u00f3n J, [\u2026] Surrall\u00e9s J. Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. <em>Nat Commun<\/em>. 2018 Mar 6;9(1):967. doi: 10.1038\/s41467-018-03433-3.[\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29511213&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>An important role of the EDC4 gene in the intricate network regulating the repair of DNA damage and in cancer development has now been uncovered. In a study recently published in Nature Communications, international researchers have elucidated this previously unknown additional function of EDC4 (enhancer of mRNA decapping 4), an RNA degradation enzyme that is [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-9697","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month - March: EDC4 - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-march-edc4\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month - March: EDC4 - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"An important role of the EDC4 gene in the intricate network regulating the repair of DNA damage and in cancer development has now been uncovered. 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