{"id":9730,"date":"2018-04-25T08:19:47","date_gmt":"2018-04-25T06:19:47","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=9730"},"modified":"2018-04-25T08:19:47","modified_gmt":"2018-04-25T06:19:47","slug":"an-evolutionarily-conserved-ribosome-rescue-pathway-maintains-epidermal-homeostasis","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/an-evolutionarily-conserved-ribosome-rescue-pathway-maintains-epidermal-homeostasis\/","title":{"rendered":"An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis"},"content":{"rendered":"<p>During translation, a number of obstacles have the potential to arrest the ribosomal movement. In yeast, several studies revealed that the evolutionarily conserved Pelota (Pelo) recognizes stalled ribosomes and dissociates ribosomal subunits. In mammals, little is known about the role of Pelo in the ribosome-rescue machinery. An international collaboration with the participation of Prof. Ibrahim Adham at the Institute of Human Genetics G\u00f6ttingen has studied conditional mouse lines in which Pelo is deleted in different epidermal stem cell lineages. They found that loss of the ribosome-rescue factor Pelo in specific epidermal stem cell lineage results in hyperproliferation and altered differentiation of these cells. By contrast, deletion of Pelo in other epidermal stem cell lineages has no effect or induces a mild phenotype. Further molecular analyses demonstrated that the Pelo deletion results in global upregulation of translation, rather than affecting the expression of specific genes. These results reveal that the ribosome-rescue machinery is essential for mammalian tissue homeostasis.<\/p>\n<p>The results of the study have been published in <em>Nature<\/em>.<\/p>\n[vc_column_text] Liakath-Ali K, Mills EW, Sequeira I, Lichtenberger BM, Pisco AO, Sipil\u00e4 KH, Mishra A, Yoshikawa H, Wu CC, Ly T, Lamond AI, Adham IM, Green R, Watt FM. An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis. <em>Nature<\/em>. 2018 Apr;556(7701):376-380. doi: 10.1038\/s41586-018-0032-3. Epub 2018 Apr 11. [\/vc_column_text]\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29643507&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>During translation, a number of obstacles have the potential to arrest the ribosomal movement. In yeast, several studies revealed that the evolutionarily conserved Pelota (Pelo) recognizes stalled ribosomes and dissociates ribosomal subunits. In mammals, little is known about the role of Pelo in the ribosome-rescue machinery. An international collaboration with the participation of Prof. Ibrahim [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[51,52],"tags":[],"class_list":["post-9730","post","type-post","status-publish","format-standard","hentry","category-news","category-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/an-evolutionarily-conserved-ribosome-rescue-pathway-maintains-epidermal-homeostasis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"During translation, a number of obstacles have the potential to arrest the ribosomal movement. In yeast, several studies revealed that the evolutionarily conserved Pelota (Pelo) recognizes stalled ribosomes and dissociates ribosomal subunits. In mammals, little is known about the role of Pelo in the ribosome-rescue machinery. 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