{"id":9872,"date":"2018-07-04T14:16:51","date_gmt":"2018-07-04T12:16:51","guid":{"rendered":"https:\/\/www.humangenetik-umg.de\/?p=9872"},"modified":"2018-07-04T14:16:51","modified_gmt":"2018-07-04T12:16:51","slug":"gene-of-the-month-june-magoh","status":"publish","type":"post","link":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/","title":{"rendered":"Gene of the Month &#8211; June: MAGOH"},"content":{"rendered":"<p>Genetic or functional dependencies are often used by cancer cells to compensate the loss of function of one gene by the function of another gene in order to persist. By using genome-wide analyses and CRISPR technology, a group of U.S. scientists has now studied hundreds of cancer cell lines and discovered that such a genetic dependency exists between the two paralog genes <em>MAGOH <\/em>and <em>MAGOHB<\/em>. The two genes are functionally redundant and encode key components of the exon-junction complex, a multiprotein complex that is deposited on mRNA during splicing and contributes to various downstream processes like transport and stability of mRNA and nonsense-mediated decay. A deletion of the <em>MAGOH <\/em>gene often occurs due to loss of the short arm of chromosome 1 in cancer. In their study, the researchers investigated whether MAGOHB inhibition in the setting of decreased MAGOH dosage affects the survival of cancer cells by perturbing RNA splicing and RNA surveillance. Their results suggest that in genetically defined subsets of tumors, MAGOH and MAGOHB loss confers a vulnerability to cancer cells. This might inform the development of targeted therapeutic approaches in cancers with chromosome 1p deletion.<\/p>\n<p>The results of this study have been published in <em>Nature Genetics<\/em>.<\/p>\n[mk_button dimension=&#8221;flat&#8221; size=&#8221;medium&#8221; icon=&#8221;mk-icon-long-arrow-right&#8221; icon_anim=&#8221;side&#8221; url=&#8221;https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29955178&#8243; target=&#8221;_blank&#8221; bg_color=&#8221;#006699&#8243; btn_hover_bg=&#8221;#000000&#8243; btn_hover_txt_color=&#8221;#ffffff&#8221;]Article in PubMed[\/mk_button][mk_padding_divider size=&#8221;30&#8243;]\n","protected":false},"excerpt":{"rendered":"<p>Genetic or functional dependencies are often used by cancer cells to compensate the loss of function of one gene by the function of another gene in order to persist. By using genome-wide analyses and CRISPR technology, a group of U.S. scientists has now studied hundreds of cancer cell lines and discovered that such a genetic [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[54],"tags":[],"class_list":["post-9872","post","type-post","status-publish","format-standard","hentry","category-gene-of-the-month"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gene of the Month - June: MAGOH - Institut f\u00fcr Humangenetik<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gene of the Month - June: MAGOH - Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"og:description\" content=\"Genetic or functional dependencies are often used by cancer cells to compensate the loss of function of one gene by the function of another gene in order to persist. By using genome-wide analyses and CRISPR technology, a group of U.S. scientists has now studied hundreds of cancer cell lines and discovered that such a genetic [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/\" \/>\n<meta property=\"og:site_name\" content=\"Institut f\u00fcr Humangenetik\" \/>\n<meta property=\"article:published_time\" content=\"2018-07-04T12:16:51+00:00\" \/>\n<meta name=\"author\" content=\"KB\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"KB\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/\"},\"author\":{\"name\":\"KB\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"headline\":\"Gene of the Month &#8211; June: MAGOH\",\"datePublished\":\"2018-07-04T12:16:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/\"},\"wordCount\":246,\"commentCount\":0,\"articleSection\":[\"Gene of the Month\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/\",\"name\":\"Gene of the Month - June: MAGOH - Institut f\u00fcr Humangenetik\",\"isPartOf\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\"},\"datePublished\":\"2018-07-04T12:16:51+00:00\",\"author\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.humangenetik-umg.de\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gene of the Month &#8211; June: MAGOH\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#website\",\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/\",\"name\":\"Institut f\u00fcr Humangenetik\",\"description\":\"Institut f\u00fcr Humangenetik der Universit\u00e4tsmedizin G\u00f6ttingen\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.humangenetik-umg.de\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/521bbb2a6ceb55060a1ef5eccb794675\",\"name\":\"KB\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.humangenetik-umg.de\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/599107e4ecdfb329c5aa3823e054ce14?s=96&d=mm&r=g\",\"caption\":\"KB\"},\"url\":\"https:\/\/www.humangenetik-umg.de\/en\/author\/boss\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gene of the Month - June: MAGOH - Institut f\u00fcr Humangenetik","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.humangenetik-umg.de\/en\/gene-of-the-month-june-magoh\/","og_locale":"en_US","og_type":"article","og_title":"Gene of the Month - June: MAGOH - Institut f\u00fcr Humangenetik","og_description":"Genetic or functional dependencies are often used by cancer cells to compensate the loss of function of one gene by the function of another gene in order to persist. 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