Main Research Areas
Our Institute builds on a dynamic and productive network of scientists. While our research groups vary in their major areas of interest, they all make use of the latest methods and technologies to find answers to their research questions. They address fundamental cellular processes such as “Genomic Instability and Aging” (Wollnik) or “Hedgehog/Patched Signaling Pathway & Tumor Development” (Hahn). In parallel, they also focus on genetic and molecular causes of rare skeletal and connective tissue disorders (Kornak) and pathomechanisms underlying specific diseases as, for example, in projects on Colon Cancer and Prostrate Carcinoma (Burfeind and Kaulfuß), Hodgkin Lymphoma (Yigit), CHARGE Syndrome (Pauli) and congenital progeria syndromes (Wollnik).
We apply an array of methods including NGS-based high-throughput analyses (e.g. whole-genome and whole-exome sequencing, RNA-Seq, Chip-Seq), state-of-the-art molecular biology methods and different cellular systems and model organisms (e.g. mouse, zebrafish). Please have a look at the profiles of our individual research groups to learn more about their projects and methods.
A distinguishing feature of the Institute is our “MutationMining Team” (MM Team): It unites currently 17 clinicians and researchers of varying background who combine their expertise to analyze and interpret data generated by whole-genome/exome or Mendeliome sequencing studies. Their aim is to identify novel disease-associated genes and variants for conditions that are being investigated in internal and external collaborations.