Main Research Areas
Our Institute provides a modern and dynamic infrastructure for our researchers to produce findings that expand our understanding of fundamental biological processes, improve diagnostics of genetic disorders and inform development of future therapeutic options for the benefit of patients.
The range of our research activities is wide. This is a selection of key issues and disorders that our research groups focus on:
Pathogenesis of cancer
What signalling pathways interact in the pathogenesis of rhabdomyosarcoma and pituitary adenoma?
⇒ Section of Molecular Developmental Genetics
What genes and gene variants are involved in familial cancers?
⇒ Research groups Kaulfuß, Wollnik
Bioinformatic analysis of genome dynamics
Our NGS-based analyses generate enormous amounts of complex data. We develop and establish in-house bioinformatic pipelines that allow us to apply mathematical and statistical tools for processing, analyzing and interpreting data in a manner that provides new insights into various aspects of genome dynamics.
⇒ Research group Zibat
We investigate molecular processes in single cells, in various tissues, at different times in the course of development, in healthy organisms and in disease. For this, we use state-of-the-art next-generation sequencing technology including genome sequencing, transcriptome analysis, single-cell sequencing and other methods. Experiments in cell systems as, e.g., iPS cells, organoids, bone-on-a-chip or in model organisms (mouse, zebrafish) improve our understanding of how mutations impact on protein function and how proteins interact in molecular mechanisms and signalling cascades.