Gene of the Month – March: SYK

Mutations in the SYK gene are responsible for a newly described phenotype with severe immunodeficiency, multi-organ inflammatory disease involving the intestines, liver, skin, joints and central [...]

Gene of the Month – February: EN1

Dysregulated expression of the gene EN1, or engrailed-1, due to a remarkable genetic mechanism, leads to a rare congenital disorder with severe limb malformations. This is reported in Nature by [...]

Gene of the Month – January: BCL11A

Editing of the BCL11A gene by CRISPR/Cas9 might be a future gene therapy approach to treat sickle cell disease and beta thalassemia. This is suggested by the first results of a pilot study led by [...]

Gene of the Month – December: WAPL

WAPL encodes the cohesin release factor WAPL. Cohesin, a ring-shaped protein complex of several subunits, plays an essential role in maintaining sister chromatid cohesion for example during DNA [...]

Gene of the Month – November: CLCN6

A point mutation in CLCN6 has been identified as the genetic cause of a severe, lysosomal neurodegenerative disorder. Researchers from Germany, Italy and the United States detected the identical [...]

Gene of the Month – October: SUFU

Heterozygous truncating variants of the SUFU negative regulator of hedgehog signaling (SUFU) gene cause congenital oculomotor apraxia (COMA), a rare eye movement disorder. Patients with this [...]

Developing personalized therapy strategies for pancreatic cancer: UMG receives DFG funding

Developing new and specific therapeutic options for pancreatic cancer (PDAC) is the overall goal of a new Clinical Research Unit at the University Medical Center Göttingen, to which the German [...]