Researchers have developed a pioneering, specific, personalized gene therapy for a newborn with a rare and life-threatening urea cycle metabolism disorder. This has been reported in the New [...]
SLC7A11 enables a slow proton efflux from lysosomes and thus plays a vital role in maintaining the acidic environment inside these cellular organelles. This has been demonstrated by a new study [...]
Researchers have uncovered a novel neurodevelopmental disorder featuring multiple congenital anomalies that is linked to variants in the MED16 gene. Published in the American Journal of Human [...]
Silencing the PCSK9 gene through epigenetic editing may be a novel and promising future strategy to treat hypercholesterolemia. In a study published in Nature Medicine, researchers describe the [...]
The pivotal role of the oncostatin M (OSM) protein in hematopoiesis in humans is underscored by a recent study published in the Journal of Clinical Investigation. Researchers investigated three [...]
Researchers have identified IL-23R as an aging and cellular senescence biomarker and a potential target for future strategies to counteract aging-associated conditions. The authors of a study [...]
A central, previously unknown role of the PNUTS complex in gene transcription depending on RNA polymerase II has been uncovered. According to a study published in Molecular Cell, the PNUTS [...]
Errors introduced by DNA polymerase ε (POLE) during DNA replication contribute significantly to the occurrence of C-to-T mutations at methylated CpG dinucleotides. A study published in Nature [...]
Centromeric protein A, known as CENPA, interacts with epigenetically altered centromeric RNA, thereby facilitating the division of cancer cells. This finding is reported in a recent study [...]
DNA methyltransferase DAMT-1 catalyzes in C. elegans a specific form of epigenetic mark, adenosine N6-methylation (6mA), on mitochondrial DNA (mtDNA). Impaired regulation of this modification [...]
