­Schwerpunkt­­professur
Molekulare Entwicklungsgenetik

Julia Bauer
Doktorandin (Biologie)
julia.heise@med.uni-goettingen.de

Dominik Simon Botermann
Doktorand (Biologie)
dominik.botermann@med.uni-goettingen.de

Nadine Brandes
Doktorandin (Biologie)
nadine.brandes@med.uni-goettingen.de

Anke Frommhold
Technische Assistentin
anke.frommhold@med.uni-goettingen.de

Ina Hess
Technische Assistentin
ihess@gwdg.de

PD Dr. rer. nat. Anja Uhmann
Laborleitung
auhmann@gwdg.de

Prof. Dr. med. Heidi Hahn
Abteilungsleitung
hhahn@gwdg.de

Projekte

Publikationen

Interaktionen der Hedgehog und Ras Signalwege beim Rhabdomyosarkom

Das Rhabdomyosarkom (RMS) ist das häufigste Weichteilsarkom bei Kindern. Wir konnten zeigen, dass der Hedgehog (Hh) Signalweg in Subgruppen dieser Tumoren sowohl beim Menschen als auch in der Maus aktiviert ist. Oft weisen RMS auch onkogene Ras Mutationen auf, die alle 3 Ras Gene betreffen können. Da Ras die Aktivität des Hh Signalwegs beeinflussen kann, untersuchen wir, ob onkogene Ras Mutationen das Wachstum von Hh-assoziierten RMS beeinflussen. Hierzu verwenden wir Zelllinien und Mausmodelle.
(Julia Bauer/Heidi Hahn)

Gezielte Therapie von Hedgehog-assoziierten Rhabdomyosarkomen

Kinder mit rezidivierenden Rhabdomyosarkomen (RMS) haben eine sehr schlechte Prognose. Dies zeigt den dringenden medizinischen Handlungsbedarf hinsichtlich der Entwicklung neuer Therapieansätze. Wir konnten zeigen, dass der Hedgehog (Hh) Signalweg in Subgruppen dieser Tumoren aktiviert ist, was mit einer schlechteren Prognose korreliert. In diesem Projekt untersuchen wir die Wirkung von Hh-Inhibitoren auf das RMS Wachstum. Hierzu verwenden wir Zelllinien und Mausmodelle.
(Natalie Geyer/Heidi Hahn)

Die Rolle von LEF1 beim Rhabdomyosarkom

Das Rhabdomyosarkom (RMS) entsteht aus undifferenzierten Muskelvorläuferzellen und ist das häufigste Weichteilsarkom bei Kindern. Obwohl der Wnt Signalweg eine wichtige Rolle bei der Entwicklung des Skelettmuskels spielt, gibt es nur wenige Informationen über seine Funktion beim RMS. Wir untersuchen die Rolle von LEF1, welches eine wichtige Komponente des Wnt Signlawegs ist, in RMS Zelllinien und Mausmodellen.
(Heidi Hahn)

Die Rolle des Hedgehog Signalwegs beim Plattenepithelkarzinom der Haut

Die Rolle des Hedgehog (Hh) Signalwegs beim Plattenepithelkarzinom der Haut (cSCC) ist unklar. In diesem Projekt wollen wir diese Rolle verstehen und versuchen zudem, die potentiellen molekularen Interaktionen des Hh Signalwegs mit den RAS/ERK, PI3K/AKT oder mTOR Signalwegen zu entwirren.
(Heidi Hahn)

Die Rolle des Hedgehog Signalwegs in der adulten Hypophyse und bei der Entstehung von Hypophysenadenomen

Der Hedgehog (HH) Signalweg spielt eine wichtige Rolle bei der Entwicklung der Hypophyse, einer Hormondrüse mit übergeordneter Rolle bei der Regulation des gesamten neuroendokrinen Systems. Über die Funktion dieses Signalwegs in der adulten Hypophyse und bei der Entstehung von Hypophysenadenomen ist wenig bekannt. Anhand von Mausmodellen und humanen Gewebeproben untersuchen wir, welchen Einfluss der Signalweg auf die Entstehung Hormon-exprimierender Zellen, die Hormonregulation und die Entstehung von Adenomen hat, und ob Smoothened-Inhibitoren für die Behandlung von Hypophysentumoren eingesetzt werden können.
(Dominik Simon Botermann/Anja Uhmann)

Adulte Stammzellen der Haut und deren Rolle bei der Entstehung von Hautkrebs

Adulte Stammzellen der Haut sind essentiell für die natürliche Regeneration der Haut und für die Wundheilung. Jedoch spielen sie auch eine wichtige Rolle bei der Entstehung von Hauttumoren. In diesem Projekt untersuchen wir anhand von Mausmodellen und humanen Hautproben eine von uns erstmals beschriebene stammzellartige Zellpopulation der Haut und deren Funktion in der normalen Homöostase sowie deren Rolle bei der Entstehung von Hautkrebs.
(Nadine Brandes/Anja Uhmann)

Publikationen AG Hahn

2017

2016

2015

2014

2013

2012 und früher

2017

Indian Hedgehog Suppresses a Stromal Cell–Driven Intestinal Immune Response
Westendorp BF, Büller NVJA, Karpus ON, van Dop WA, Koster J, Versteeg R, Koelink PJ, Snel CY, Meisner S, Roelofs JJTH, Uhmann A, Ver Loren van Themaat E, Heijmans J, Hahn H, Muncan V, Wildenberg ME, van den Brink GR
Cellular and Molecular Gastroenterology and Hepatologyt 2017 Sept

Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands
Almazán-Moga A, Zarzosa P, Molist C, Velasco P, Pyczek J, Simon-Keller K, Giralt I, Vidal I, Navarro N, Segura MF, Soriano A, Navarro S, Tirado OM, Ferreres JC, Santamaria A, Rota R, Hahn H, Sánchez de Toledo J, Roma J, Gallego S
Br J Cancer 2017 Sep 7. doi: 10.1038/bjc.2017.305. [Epub ahead of print]

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors
Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP
Development 2017 Sep 15;144(18):3289-3302. doi: 10.1242/dev.153387

LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma
Dräger J, Simon-Keller K, Pukrop T, Klemm F, Wilting J, Sticht C, Dittmann K, Schulz M, Leuschner I, Marx A, Hahn H
Oncotarget 2017 Jan 10;8(2):3259-3273. doi: 10.18632/oncotarget.13887

2016

Hedgehog Controls Quiescence and Activation of Neural Stem Cells in the Adult Ventricular-Subventricular Zone
Daynac M; Faure H; Mouthon MA; Gauthier L; Hahn H; Traiffort E; Boussin FD; Ruat M
Stem Cell Reports 2016 Oct 11 Vol. 7, 1-14

Arsenic trioxide induces Noxa-dependent apoptosis in rhabdomyosarcoma cells and synergizes with antimicrotubule drugs
Meister MT; Boedicker C; Graab U; Hugle M; Hahn H; Klingebiel T; Fulda S
Cancer Letter 2016 Aug 10;381(2):287-295.

Hedgehog signaling activation induces stem cell proliferation and hormone release in the adult pituitary gland
Pyczek J; Buslei R; Schult D; Hölsken A; Buchfelder M; Heß I; Hahn H; Uhmann A
Scientific Report 2016 Apr 25;6:24928. doi: 10.1038/srep24928.

Hedgehog/Patched-associated rhabdomyosarcoma formation from Delta1-expressing mesodermal cells
Nitzki F; Cuvelier N; Dräger J; Schneider A; Braun T; Hahn H.
Oncogene 2016 Jun 2;35(22):2923-31. doi: 10.1038/onc.2015.346. Epub 2015 Sep 21.

2015

A functional and putative physiological role of calcitriol in Patched/Smoothened interaction
Linder B; Weber S; Dittmann K; Adamski J; Hahn H; Uhmann A
J Biol Chem. 2015 Jun 30. pii: jbc.M115.646141.

Hedgehog inhibitors in rhabdomyosarcoma: a comparison of 4 compounds and responsiveness of 4 cell lines
Ridzewski R; Rettberg D; Dittmann K; Cuvelier N; Fulda S; Hahn H
Front Oncol. 2015 Jun 8;5:130. doi: 10.3389/fonc. 2015.00130.

Oncogenic RAS mutants confer resistance of rhabdomyosarcoma cells to oxidative stress-induced ferroptotic cell death
Schott C; Graab, U; Cuvelier N; Hahn, H; Fulda S
Front Oncol. 2015 Jun 22;5:131. doi: 10.3389/fonc.2015.00131.

Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy
Nitzki F; Tolosa EJ; Cuvelier N; Frommhold A; Salinas-Riester G; Johnsen SA; Fernandez-Zapico ME; Hahn H.
Oncotarget 2015 Apr 20;6(11):9113-24

Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma
Graab U; Hahn H; Fulda S
Oncotarget 2015 Apr 20;6(11):8722-35

2014

Genetic activation of Hedgehog signaling promotes adult neural stem cell symmetric divisions in the subventricular zone
Ferent J; Cochard L; Hahn H; Ruat M; Traiffort E
Stem Cell Reports. 2014 Aug 12;3(2):312-23

Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice
König S; Nitzki F; Uhmann A; Dittmann K; Theiss J; Herrmann M; Reichardt HM; Schwendener R; Pukrop T; Schulz-Schaeffer W; Hahn H
PLoS One. 2014 Apr 1;9(4):e93555

DMBA/TPA treatment is necessary for BCC formation from Patched deficient epidermal cells in Ptchflox/floxCD4Cre+/- mice
Uhmann A; Heß I; Frommhold A; König S; Zabel S; Nitzki F; Dittmann K; Lühder F; Christiansen H; Reifenberger J; Schulz-Schaeffer W; Hahn H
J Invest Dermatol. 2014 Oct;134(10):2620-9

Interaction of Hedgehog and Vitamin D Signaling pathways in Basal Cell Carcinomas
Albert B and Hahn H
Chapter in “Sunlight, Vitamin D and Skin Cancer, Second Edition”, edited by Jörg Reichrath 2014, Adv Exp Med Biol. 2014;810:329-41.

Inactivation of patched1 in chondrocytes causes spinal ankylosis without inflammation
Dittmann K; Wuelling W; Uhmann A; Nitzki F; Dullin C; Syrbe U; Sieper J; Hahn H; Schweyer S; Vortkamp A; Wienands J
Arthritis Rheumatol. 2014 Apr;66(4):831-40

2013

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK4 (BLP)
König S; Regen T; Dittmann K; Engelke M; Wienands J; Schwendener R; Hanisch UK; Pukrop T; Hahn H
Cancer Immunol Immunother. 2013 Oct;62(10):1587-97

The Hedgehog receptor patched1 in T cells is dispensable for adaptive immunity in mice
Michel KD; Uhmann A; Dressel R; van den Brandt J; Hahn H; Reichardt HM
PLOS ONE 1 April 2013 Volume 8 Issue 4 e61034

Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine esophagus
van Dop WA; Rosekrans SL; Uhmann A; Jaks V; Offerhaus GJ; van den Bergh Weerman MA; Kasper M; Heijmans J; Hardwick JC; Verspaget HW; Hommes DW; Toftgård R; Hahn H; van den Brink GR
GUT 2013 Mar;62(3):348-5

Inactivation of patched1 in mice leads to development of gastrointestinal stromal-like tumors that express pdgfrα but not kit
Pelczar P; Zibat Z; van Dop WA; Heijmans J; Bleckmann A; Gruber W; Nitzki F; Uhmann A; Guijarro MV; Hernando E; Dittmann K; Wienands J; Dressel R; Wojnowski L; Binder C; Taguchi T; Beissbarth T; Hogendoorn PCW; Antonescu CR; Rubin BP; Schulz-Schaeffer W; Aberger F; van den Brink GR; Hahn H
Gastroenterology 2013 Jan;144(1):134-144.e6.

2012 und früher

PI3K Inhibition Enhances Doxorubicin-Induced Apoptosis in Sarcoma Cells
Marklein D, Graab U, Naumann I, Yan T, Ridzewski R, Nitzki F, Rosenberger A, Dittmann K, Wienands J, Wojnowski L, Fulda S, Hahn H
PLoS One 2012;7(12):e52898.

Patched knockout mouse models of Basal Cell Carcinoma
Nitzki F; Becker M; Frommhold A; Schulz-Schaeffer W; Hahn H
J Skin Cancer 2012;2012:907543.

Calcitriol inhibits Hedgehog signaling and induces vitamin D receptor-signaling and differentiation in the patched mouse model of embryonal rhabdomyosarcoma
Uhmann A; Niemann H; Lammering B; Henkel C; Hess I; Rosenberger A; Dullin C; Schraepler A; Schulz-Schaeffer W; Hahn H
Sarcoma 2012;2012:357040.

Antitumoral effects of Calcitriol in Basal Cell Carcinoma involve inhibition of Hedgehog Signaling and induction of Vitamin D Receptor Signaling and Differentiation
Uhmann A; Niemann H; Lammering B; Henkel C; Hess I; Nitzki F; Fritsch A; Rosenberger A; Dullin C; Schraepler A; Reifenberger J; Schweyer S; Pietsch T; Strutz F; Schulz-Schaeffer W; Hahn H
Mol Cancer Ther 2011;10:2179-2188

Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1 mutant mice
Nitzki F; Zibat A; Frommhold A; Schneider A; Schulz-Schaeffer W; Braun T; Hahn H
Oncogene 2011 Oct 27;30(43):4428-36.

T cell development critically depends on prethymic stromal Patched expression
Uhmann A; van den Brandt J; Dittmann K; Heß I; Dressel R; Binder C; Lühder F; Christiansen H; Fassnacht M; Bhandoola A; Wienands J; Reichardt HM; Hahn H
The Journal of Immunology 2011, 186: 3383–3391.

Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene negative alveolar rhabdomyosarcoma
Zibat A; Missiaglia E; Rosenberger A; Pritchard-Jones K; Shipley J; Hahn H; Fulda S
Oncogene 2010 Dec 2;29(48):6323-30.

Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch mutant mice via CaMKII
Nitzki F; Zibat A; König S; Wijgerde M; Rosenberger A; Brembeck F; Carstens PO; Frommhold A; Uhmann A; Klingler S; Reifenberger J; Pukrop T; Aberger F; Schulz-Schaeffer W; Hahn H
Cancer Research 2010 Apr 1;70(7):2739-48.

Comment on „Direct Hematological Toxicity and Illegitimate Chromosomal Recombination Caused by the Systemic Activation of CreERT2”
Uhmann A; Dittmann K; Wienands J; Hahn H
The Journal of Immunology 2009 Sep 1;183(5):2891; author reply 2891-2.

Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts
Zibat A; Uhmann A; Nitzki F; Wijgerde M; Frommhold A; Heller T; Armstrong V; Wojnowski L; Quintanilla-Martinez L; Reifenberger J; Schulz-Schaeffer W; Hahn H
Carcinogenesis 2009 30(6):918-26.

Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the Hedgehog pathway
van Dop WA; Uhmann A; Wijgerde M; Heijmans J; Offerhaus GJ; van den Bergh Weerman MA; Hommes DW; Hardwick JC; Hahn H; van den Brink GR
Gastroenterology 2009 136(7):2195-2203.e1-7.

Antitumor effects of a combined 5-aza-2’deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice
Ecke I; Petry F; Rosenberger A; Tauber S; Mönkemeyer S; Hess I; Dullin C; Kimmina S; Pirngruber J; Johnsen SA; Uhmann A; Nitzki F; Wojnowski L; Schulz-Schaeffer W; Witt O; Hahn H
Cancer Research 2009 69:887-95

Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth
Ecke I; Rosenberger A; Obenauer S; Dullin; Aberger F; Kimmina S; Schweyer S; Hahn H
Mol Carcinogenesis 2008 47:361-72

Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice
Eichenmuller M; Bauer R; Von Schweinitz D; Hahn H; Kappler R
Int J Oncol. 2007 Aug;31(2):405-12.

The Hedgehog receptor Patched controls lymphoid lineage commitment
Uhmann A; Dittmann K; Nitzki F; Dressel R; Koleva M; Frommhold A; Zibat A; Binder C; Adham I; Nitsche M; Heller T; Armstrong V; Schulz-Schaeffer W; Wienands J; Hahn H
Blood 2007 Sep 15;110(6):1814-23.

Identification of a genetic contamination in a commercial mouse strain using two panels of polymorphic markers
Nitzki F; Kruger A; Reifenberg K; Wojnowski L; Hahn H
Lab Anim. 2007 Apr;41(2):218-28.

Mode of PTCH1/Ptch1-associated tumor formation: insights from mutant Ptch1 mice
Hahn H
Hedgehog-Gli signaling in Human disease. Editor: Ariel Ruiz I Altaba. Landes Bioscience/Eurekah. 2006

Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice
Pazzaglia S; Tanori M; Mancuso M; Rebessi S; Leonardi S; Di Majo V; Covelli V; Atkinson MJ; Hahn H; Saran S
Oncogene 2006, 25(8), 1165-73

NAD(P)H oxidase and MRP genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity
Wojnowski L; Kulle B; Schirmer M; Schlüter G; Schmidt A; Rosenberger A; Vonhof S; Bickeböller H; Toliat MR; Suk EK; Tzvetkov M; Kruger A; Seifert, S; Kloess M: Hahn H; Loeffler M; Nürnberg P; Pfreundschuh M; Trümper L; Brockmöller J; Hasenfuss G
Circulation 2005, 112(24), 3754-62

A model for PTCH1/Ptch1-associated tumors comprising mutational inactivation and gene silencing
Uhmann A; Ferch U; Bauer R; Tauber S; Arziman Z; Chen C; Hemmerlein B; Wojnowski L; Hahn H
Int. J. Oncology 2005, 27(6),1567-75

Pseudotrisomy 13: clinical findings and genetic implications
Schulz S; Gerloff C; Kalinski T; Mawrin C; Kanakis D; Haas D; Hahn H; Wieacker P
Fetal Diagn Ther. 2005, 20(6), 501-3

The Fem1a gene is down-regulated in rhabdomyosarcoma
Ventura-Holman T; Hahn H; Subauste JS; Maher JF
Tumour Biol. 2005, 26(6), 294-299

Pleiotropic effects of sonic hedgehog on muscle satellite cells
Koleva M; Kappler R; Vogler M; Herwig A; Fulda S; Hahn H
Cell Mol Life Sci. 2005, 62(16), 1863-70.

Functions of Sorting Nexin17 Domains and Recognition Motif for P-selectin Trafficking
Knauth P; Schlüter T; Czubayko M; Kirsch C; Florian V; Schreckenberger S; Hahn H; Bohnensack R.
J Mol Biol. 2005, 347(4), 813-25

Profiling the molecular difference between Patched1– and p53-dependent rhabdomyosarcoma
Kappler R; Bauer R; Calzada-Wack J; Rosemann M; Hemmerlein B; Hahn H
Oncogene 2004, 23(54), 8785-95

Analysis of the PTCH1 signaling pathway in ovarian dermoids
Levanat S; Kappler R; Hemmerlein B; Döring P; Musani V; Komar A; Oreskovic S; Pavelic B; Hahn H
Int. J. Mol. Medicine 2004, 14(5), 793-799

Genetic mapping of a major susceptibility locus to murine rhabdomyosarcoma
Hahn H; Nitzki F; Schorban T; Hemmerlein B; Threadgill D; Rosemann M
Genomics 2004, 84(5), 853-858

Tumor associated E-cadherin mutations do not induce Wnt target gene expression, but effect E-cadherin repressors
Laux H; Mader MT; Smida J; BudcziesJ; Kappler K; Hahn H; Blöchinger M; Schnitzbauer U; Eckardt-Schupp F; Höfler H; Becker KF
Lab Invest. 2004, 84(10), 1372-1386

Transcriptional up-regulation of Gadd45a in Patched-associated medulloblastoma
Kappler R; Heß I; Schlegel J; Hahn H
Int. J. Oncology 2004, 25(1), 113-121

Modulation of Patched-associated Susceptibility to Radiation Induced Tumorigenesis by Genetic Background
Pazzaglia S; Mancuso M; Tanori M; Atkinson MJ; Merola P; Rebessi S; Di Majo V; Covelli V; Hahn H; Saran A
Cancer Research 2004, 64(11), 3798-806

Basal Cell Carcinoma and its Development: Insights from Radiation Induced Tumors in Ptch1 Deficient Mice
Mancuso M; Pazzaglia S; Tanori M; Hahn H; Merola P; Rebessi S; Atkinson MJ; Di Majo V; Covelli V; Saran A
Cancer Research 2004, 64(3), 934-41.

Molecular characterisation of Patched-associated rhabdomyosarcoma
Kappler R; Calzada-Wack J; Schnitzbauer U; Piontek G; Graedler F; Adamski J; Heinzmann U; Schlegel J; Hemmerlein B; Quintanilla-Martinez L; Hahn H
J. of Pathology 2003, 200(3), 348-56

Gene expression analysis of murine cells producing of amphotropic mouse leukemia viruses at 32oC and 37oC cultivation temperature
Beer C; Buhr P; Hahn H; Laubner D; Wirth M
J Gen Virology 2003, 84, 1677-1686

The Patched Polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk
Chang-Claude J; Dunning A; Schnitzbauer U; Galmbacher P; Tee L; Wjst M; Chalmers J; Zemzoum I; Harbeck N; Pharoah PDP; Hahn H
Int. J. Cancer 2003 March 1;103(6):779-83

High Incidence of Medulloblastoma Following X Ray-Irradiation of Newborn ptch Heterozygous Mice
Pazzaglia S; Mancuso M; Atkinson M; Tanori M; Rebessi S; Di Majo V; Covelli V; Hahn H; Saran A
Oncogene 2002 Oct 24;21(49):7580-4

CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer
Pharoah PD; Oliveira C; Machado JC; Keller G; Vogelsang H; Laux H; Becker KF; Hahn H; Paproski SM; Brown LA; Caldas C; Huntsman D
Int. J. Cancer 2002 Sep 10;101(2):196-197.

Analysis of the PTCH coding region in human rhabdomyosarcoma
Calzada-Wack J; Schnitzbauer U; Walch A; Wurster KH, Kappler R; Nathrath M; Hahn H
Hum. Mutat 2002 Sep;20(3):233-4.

Unbalanced overexpression of the mutant allele in murine Patched mutants
Calzada-Wack J; Kappler R; Schnitzbauer U; Richter T; Nathrath M; Rosemann M; Wagner SN; Hein R; Hahn H
Carcinogenesis 2002; 23(5):727-734

Absence of delta-9-tertahydrocannabinol dysphoric effects in dynorphin-deficient mice
Zimmer A; Valjent E; Konig M; Zimmer AM; Robledo P; Hahn H; Valverde O; Maldonado R
J. Neurosci 2001; 21 (23): 9499-9505.

Genetic evidence that Sil is required for the sonic hedgehog response pathway
Izraeli S; Lowe LA; Bertness VL; Campaner S; Hahn H; Kirsch IR; Kuehn MR
Genesis 2001; 31(2): 72-7.

Basalzellnävussyndrom
Molekularmedizinische Grundlagen von hereditären Tumorerkrankungen, Detlev Ganten und Klaus Ruckpaul (Hrsg.) Springer-Verlag Berlin Heidelberg 2001

Neurological and psychiatric manifestations in a family with a mutation in exon 2 of the GTP cyclohydrolase gene
Hahn H; Trant MR; BrownsteinMJ; Harper RA; Milstien S; Butler IJ
Archives of Neurology 2001; 58 (5): 749-755

Genetically determined susceptibility markers in skin cancer and their application to chemoprevention
Hahn H
IARC Scientific Publications 2001, 154: 93-101

Patched target IGF2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
Hahn H; Wojnowski L; Specht K; Kappler R; Calzada-Wack J; Potter D; Zimmer AM; Müller U; Samson E; Quintinilla-Martinez; Zimmer A
JBC 2000 Sept; 275 (37): 28341-4

The patched signaling pathway in tumorigenesis and development: lessons from animal models
Hahn H; Wojnowski L; Miller G; Zimmer A
J Mol Med 1999 Feb; 77:459-468

Craf-1 protein kinase is essential for mouse developement
Wojnowski L; Stancato LF; Zimmer AM; Hahn H; Beck TW; Larner AC; Rapp UR; Zimmer A
Mech Dev 1998 Aug; 76(1-2):141-9.

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model for Gorlin syndrome
Hahn H; Wojnowski L; Zimmer AM; Hall J; Miller G; Zimmer A
Nat Medicine 1998 May; 4(5): 619-622

Endothelial apoptosis in Braf-deficient mice
Wojnowski L; Zimmer AM; Beck TW; Hahn H; Bernal R; Rapp UR; Zimmer A
Nat Genet 1997 July 16:293-297

Mutations of the human homologue of Drosophila patched in the nevoid basal cell carcinoma syndrome
Hahn H; Wicking C; Zaphiropoulos P; Gailani M; Shanley S; Chidambaram A; Vorechovsky I; Holmberg E; Unden A; Gillies S; Negus K; Smyth I; Pressman C; Leffell D; Gerrard B; Goldstein A; Wainright B; Toftgard R; Chenevix-Trench G; Dean M; Bale A
Cell 1996 June14; 85(6): 841-51

A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
Hahn H; Christiansen J; Wicking C; Zaphiropoulos P; Chidambaram A; Gerrard B; Vorechovsky I; Bale A; Toftgard R; Wainwright B; Dean M
JBC 1996 May 24; 271(21): 12125-8

Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis
Rosener M; Hahn H; Kranz M; Heeney J; Rethwilm A
J Med Virol 1996 Mar;48(3):222-6

Markers of foamy virus infections in monkeys, apes, and accidentally infected humans: appropriate testing fails to confirm suspected foamy virus prevalence in humans
Schweizer M; Turek R; Hahn H; Schliephake A; Netzer KO; Eder G; Reinhardt M; Rethwilm A; Neumann-Haefelin D
AIDS Res Hum Retroviruses 1995 Jan;11(1):161-70

The Raf-1 serine/threonine protein kinase
Magnuson NS; Beck T; Vahidi H; Hahn H; Smola U; Rapp UR
Semin Cancer Biol 1994 Aug;5(4):247-53

Reactivity of primate sera to foamy virus Gag and Bet proteins
Hahn H; Baunach G; Brautigam S; Mergia A; Neumann-Haefelin D; Daniel MD; McClure MO; Rethwilm A
J Gen Virol 1994 Oct;75 ( Pt 10):2635-44

Functional analysis of human foamy virus accessory reading frames
Baunach G; Maurer B; Hahn H; Kranz M; Rethwilm A
J Virol 1993 Sep;67(9):5411-8

Genotoxicity of 1,3-dichloro-2-propanol in the SOS chromotest and in the Ames test. Elucidation of the genotoxic mechanism
Hahn H; Eder E; Deininger C
Chem Biol Interact 1991;80(1):73-88

Induction of SOS repair by monofunctional methansulfonates in various Escherichia coli strains. Structure-activity relationships in comparison with mutagenicity in Salmonella typhimurium
Eder E; Favre A; Deininger C; Hahn H; Kütt W
Mutagenesis 1989;4(3):179-86

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